Alcoholic liver disease (ALD) is a significant cause of death and morbidity. Detection of liver fibrosis at an early stage could provide opportunities for more optimal management. Serum markers of liver fibros...
Authors: Julie Parkes, Indra Neil Guha, Scott Harris, William MC Rosenberg and Paul J Roderick
Liver cancer is one of the most common malignancies in the world and at the moment, there is no drug intervention effective for the treatment of liver tumours. Investigate the effect of N-acetylcysteine (NAC),...
Authors: Nelson Alexandre Kretzmann, Eduardo Chiela, Ursula Matte, Norma Marroni and Claudio Augusto Marroni
After partial hepatectomy (PHx), the liver regeneration process terminates when the normal liver-mass/body-weight ratio of 2.5% has been re-established. To investigate the genetic regulation of the terminating...
Authors: Ingvild E Nygård, Kim E Mortensen, Jakob Hedegaard, Lene N Conley, Trine Kalstad, Christian Bendixen and Arthur Revhaug
This report presents a detailed description of hepatic architecture in 46 amphibian livers by light microscopy, and extensively discusses the phylogenetic viewpoint.
Type-2 Diabetes is a major health concern in the United States and other Westernized countries, with prevalence increasing yearly. There is a need to better model and predict adverse drug reactions, drug-induc...
Authors: Vijay R More, Xia Wen, Paul E Thomas, Lauren M Aleksunes and Angela L Slitt
Programmed cell death or apoptosis is an essential process for tissue homeostasis. Hepatocyte apoptosis is a common mechanism to many forms of liver disease. This study was undertaken to test the role of ILK i...
Authors: Shashikiran Donthamsetty, Wendy M Mars, Anne Orr, Chuanyue Wu and George K Michalopoulos
Non alcoholic steatohepatitis is hypothesised to develop via a mechanism involving fat accumulation and oxidative stress. The current study aimed to investigate if an increase in oxidative stress was associate...
Authors: Mile Janevski, Kiriakos N Antonas, Melanie J Sullivan-Gunn, Maree A McGlynn and Paul A Lewandowski
Autoimmune liver diseases (AILDs) are common leading causes for liver cirrhosis and terminal stage of liver disease. They have variable prevalence among patients with liver disease and have two major clinical ...
Traditional assessment of drug-induced hepatotoxicity includes morphological examination of the liver and evaluation of liver enzyme activity in serum. The objective of the study was to determine the origin of...
Authors: Carmen Fuentealba, Monali Bera, Bart Jessen, Fred Sace, Greg J Stevens, Dusko Trajkovic, Amy H Yang and Winston Evering
The isolated perfused rat liver (IPRL) is a technique used in a wide range of liver studies. Typically livers are assessed at treatment end point. Techniques have been described to biopsy liver in the live rat...
Authors: Anthony Rowe, Lillian Zhang, Azmena Hussain, Filip Braet and Iqbal Ramzan
Biliary atresia (BA) is an idiopathic inflammatory obliterative cholangiopathy of neonates, leading to progressive biliary cirrhosis. Hepatoportoenterostomy (Kasai procedure) can cure jaundice in 30% to 80% of...
Authors: Keita Terui, Takeshi Saito, Tomoro Hishiki, Yoshiharu Sato, Tetsuya Mitsunaga and Hideo Yoshida
Situs inversus totalis is is a congenital anomaly associated with various visceral abnormalities, but there is no data about the relationship between secondary biliary cirrhosis and that condition. We here pre...
Authors: Hacı Mehmet Sökmen, Kamil Özdil, Turan Çalhan, Abdurrahman Şahin, Ebubekir Şenateş, Resul Kahraman, Adil Niğdelioğlu and Ebru Zemheri
To understand the complex and largely not well-understood apoptotic pathway and immune system evasion mechanisms in hepatitis C virus (HCV)-associated hepatocellular carcinoma (HCC) and HCV associated chronic ...
Authors: Abdel-Rahman N Zekri, Abeer A Bahnassy, Mohamed M Hafez, Zeinab K Hassan, Mahmoud Kamel, Samah A Loutfy, Ghada M Sherif, Abdel-Rahman El-Zayadi and Sayed S Daoud
Ischemic pre- and postconditioning protects the liver against ischemia/reperfusion injuries. The aim of the present study was to examine how ischemic pre- and postconditioning affects gene expression of hypoxi...
Authors: Anders R Knudsen, Anne-Sofie Kannerup, Henning Grønbæk, Kasper J Andersen, Peter Funch-Jensen, Jan Frystyk, Allan Flyvbjerg and Frank V Mortensen
Kupffer cells are well known macrophages of the liver, however, the developmental characteristics of Kupffer cells in mice are not well understood. To clarify this matter, the characteristics of Kupffer macrop...
Authors: Bryan G Lopez, Monica S Tsai, Janie L Baratta, Kenneth J Longmuir and Richard T Robertson
Under compromised biliary regeneration, transdifferentiation of hepatocytes into biliary epithelial cells (BEC) has been previously observed in rats, upon exposure to BEC-specific toxicant methylene dianiline ...
Authors: Pallavi B Limaye, William C Bowen, Anne Orr, Udayan M Apte and George K Michalopoulos
Proliferation of oval cells, the bipotent precursor cells of the liver, requires impeded proliferation and loss of hepatocytes as well as a specific micro-environment, provided by adjacent sinusoidal cells of ...
Authors: Elke Ueberham, Jan Böttger, Uwe Ueberham, Jens Grosche and Rolf Gebhardt
Hepatitis C virus (HCV) is a major cause of chronic hepatitis and a health problem affecting over 170 million people around the world. We previously studied transgenic mice that express HCV Core, Envelope 1 an...
Authors: Turaya Naas, Masoud Ghorbani, Catalina Soare, Nicole Scherling, Rudy Muller, Peyman Ghorbani and Francisco Diaz-Mitoma
ABCB4 functions as a phosphatidylcholine translocater, flipping phosphatidylcholine across hepatocyte canalicular membranes into biliary canaliculi. In people, ABCB4 gene mutations are associated with several ...
Authors: Katrina L Mealey, Jonathan D Minch, Stephen N White, Kevin R Snekvik and John S Mattoon
Temporal restriction of food availability entrains circadian behavioral and physiological rhythms in mammals by resetting peripheral oscillators. This entrainment underlies the activity of a timing system, dif...
Authors: Mauricio Díaz-Muñoz, Olivia Vázquez-Martínez, Adrián Báez-Ruiz, Gema Martínez-Cabrera, María V Soto-Abraham, María C Ávila-Casado and Jorge Larriva-Sahd
The expression of Keratin 19 (K19) was reported in a subset of hepatocellular carcinomas (HCCs). K19 positive HCCs are associated with an increased malignancy compared to K19 negative HCCs. No suitable mouse m...
Authors: Renee GHM van Sprundel, Ted SGAM van den Ingh, Valeer J Desmet, Azeam Katoonizadeh, Louis C Penning, Jan Rothuizen, Tania Roskams and Bart Spee
Perihepatitis is rare but consistently occurring extragenital manifestation of untreated Chlamydia trachomatis infection. Despite of possible liver involvement in generalized C. trachomatis infection, the ability...
Authors: Yuriy K Bashmakov, Nailya A Zigangirova, Yulia P Pashko, Lidia N Kapotina and Ivan M Petyaev
Hemodynamic changes in the liver remnant following partial hepatectomy (PHx) have been suggested to be a primary stimulus in triggering liver regeneration. We hypothesized that it is the increased sinusoidal f...
Authors: Kim E Mortensen, Lene N Conley, Ingvild Nygaard, Peter Sorenesen, Elin Mortensen, Christian Bendixen and Arthur Revhaug
Liver disease progression from chronic hepatitis C virus (HCV) infection to hepatocellular carcinoma (HCC) is associated with an imbalance between T-helper 1 and T-helper 2 cytokines. Evaluation of cytokines a...
Authors: Abdel-Rahman N Zekri, Hanaa M Alam El-Din, Abeer A Bahnassy, Naglaa A Zayed, Waleed S Mohamed, Suzan H El-Masry, Sayed K Gouda and Gamal Esmat
In adult liver, the mesenchymal cells, portal fibroblasts and vascular smooth muscle cells can transdifferentiate into myofibroblasts, and are involved in portal fibrosis. Differential expression of markers, s...
Authors: Julien Villeneuve, Fanny Pelluard-Nehme, Chantal Combe, Dominique Carles, Christine Chaponnier, Jean Ripoche, Charles Balabaud, Paulette Bioulac-Sage and Sébastien Lepreux
It has been postulated that ethanol affects hepatic sinusoidal and perisinusoidal cells. In the current experimental study, we investigated the early effect of a single intravenous dose of ethanol on the diame...
Authors: Frank Jacobs, Eddie Wisse and Bart De Geest
To minimize the necessary number of biopsies for molecular and histological research we evaluated different sampling techniques, fixation methods, and storage procedures for canine liver tissue. For addressing...
Authors: Gaby Hoffmann, Jooske Ijzer, Bas Brinkhof, Baukje A Schotanus, Ted SGAM van den Ingh, Louis C Penning and Jan Rothuizen
Golden-mantled ground squirrels (S. lateralis) are anorexic during the winter and survive by exploiting hibernation to reduce energetic demands. The liver normally plays a critical role in fueling and regulating ...
Circadian regulated physiological processes have been well documented in the mammalian liver. Phospholipases are important mediators of both cytoplasmic and nuclear signaling mechanisms in hepatocytes, and des...
Authors: Brittany M Klein, Jane B Andrews, Barbra A Bannan, Ashley E Nazario-Toole, Travis C Jenkins, Kimberly D Christensen, Sorinel A Oprisan and Elizabeth L Meyer-Bernstein
A novel transparent stock of medaka (Oryzias latipes; STII), recessive for all pigments found in chromatophores, permits transcutaneous imaging of internal organs and tissues in living individuals. Findings prese...
Authors: Ron C Hardman, Seth W Kullman and David E Hinton
Although most patients with severe acute hepatitis are conservatively cured, some progress to acute liver failure (ALF) with a high rate of mortality. Based on the evidence that over-activation of macrophages,...
In a previous study we confirmed that canine hepatic lipogranuloma, defined as lesions consisting of small round cells which contain lipid vacuoles and brown pigments in their cytoplasm, was an assembly of Kup...
Authors: Kaori Isobe, Hiroyuki Nakayama and Koji Uetsuka
Liver sinusoidal endothelial cells (LSECs) are specialized scavenger cells, with crucial roles in maintaining hepatic and systemic homeostasis. Under normal physiological conditions, the oxygen tension encount...
Authors: Inigo Martinez, Geir I Nedredal, Cristina I Øie, Alessandra Warren, Oddmund Johansen, David G Le Couteur and Bård Smedsrød
Sequential monotherapies of nucleotide analogs used in chronic hepatitis B treatment can lead to the selection of a resistance mutation to each antiviral drug.
Authors: Sylvie Larrat, Marie-Noëlle Hilleret, Raphaele Germi, Julien Lupo, Sandrine Nicod, Jean-Pierre Zarski, Jean-Marie Seigneurin and Patrice Morand
Most focal nodular hyperplasia (FNH) cases are diagnosed by chance. We studied a case of pre-FNH. We used glutamine synthase as an immunohistochemical marker for perivenous zones.
Authors: Paulette Bioulac-Sage, Hervé Laumonier, Gaëlle Cubel, Jean Saric and Charles Balabaud
Portacaval shunting in rats produces a reduction of hepatic oxidant scavenging ability. Since this imbalance in hepatic oxidant/antioxidant homeostasis could coexist with systemic changes of oxidant stress/ant...
Authors: Maria-Angeles Aller, Maria-Inmaculada García-Fernández, Fernando Sánchez-Patán, Luis Santín, José Rioja, Raquel Anchuelo, Jaime Arias and Jorge-Luis Arias
Liver fibrosis represents a significant and severe health care problem and there are no efficient drugs for therapy so far. Preventing the progression of fibrogenesis and revival endogenous repair activities i...
Authors: Kun-Lin Yang, Kuo-Chen Hung, Wen-Teng Chang and Eric IC Li
The availability of non-rodent animal models for human cirrhosis is limited. We investigated whether privately-owned dogs (Canis familiaris) are potential model animals for liver disease focusing on regenerative ...
Authors: Bart Spee, Brigitte Arends, Ted SGAM van den Ingh, Tania Roskams, Jan Rothuizen and Louis C Penning
Despite intensive studies, the clinical opportunities for patients with fibrosing liver diseases have not improved. This will be changed by increasing knowledge of new pathogenetic mechanisms, which complement...
Authors: Olav A Gressner, Ralf Weiskirchen and Axel M Gressner
Several highly proliferative human cells transiently activate telomerase, a ribonucleoprotein with reverse transcriptase activity, to counterbalance replication-associated telomere erosion and to increase stre...
Authors: Henning Wege, Anett Müller, Lars Müller, Susan Petri, Jörg Petersen and Christian Hillert
In addition to the activation of hepatic stellate cells TGF-β govern apoptosis and growth control of hepatocytes in liver injury. In non-parenchymal cells, TGF-β induces plasminogen activator inhibitor 1 (PAI-...
Authors: Lucia Wickert, Nicolas Chatain, Karin Kruschinsky and Axel M Gressner
Increased levels of circulating fatty acids caused by insulin resistance and increased adipocyte lipolysis can accumulate within the liver resulting in steatosis. This steatosis sensitizes the liver to inflamm...
Authors: Bruce Kelder, Keith Boyce, Andres Kriete, Ryan Clark, Darlene E Berryman, Sheila Nagatomi, Edward O List, Mark Braughler and John J Kopchick
Lamivudine treatment has been recently demonstrated to increase the serum albumin levels in cirrhotic patients with hepatitis B virus (HBV) infection, but the precise mechanism remains unclear. We hypothesized...
The estrogenic and xenobiotic biotransformation gene expressions are receptor-mediated processes that are ligand structure-dependent interactions with estrogen-receptor (ER) and aryl hydrocarbon receptor (AhR)...
The activation of hepatic stellate cells (HSCs) plays a pivotal role during liver injury because the resulting myofibroblasts (MFBs) are mainly responsible for connective tissue re-assembly. MFBs represent the...
Authors: Verena Proell, Irene Carmona-Cuenca, Miguel M Murillo, Heidemarie Huber, Isabel Fabregat and Wolfgang Mikulits
Radio frequency ablation (RFA) has been accepted clinically as a useful local treatment for hepatocellular carcinoma (HCC). However, intrahepatic recurrence after RFA has been reported which might be attributa...
Hepatic sinusoidal resistance is regulated by vasoactive factors including endothelin-1 (ET-1) and nitric oxide (NO). In the absence of NO, vasoconstrictor response to endothelin is expected to predominate. Th...
Authors: Andrea De Gottardi, Erwin Biecker, Abraham Koshy, Dieter Bohler, Sidney Shaw, Hans Sägesser and Jürg Reichen
Heterotrimeric G protein signaling in liver helps maintain carbohydrate and lipid homeostasis. G protein signaling is activated by binding of extracellular ligands to G protein coupled receptors and inhibited ...
Authors: Jie Huang, Victor Pashkov, Deborah M Kurrasch, Kan Yu, Stephen J Gold and Thomas M Wilkie
