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Review
Alcoholic liver disease (ALD) is a significant cause of death and morbidity. Detection of liver fibrosis at an early stage could provide opportunities for more optimal management. Serum markers of liver fibros...
Comparative Hepatology 2012 11:5
Published on: 28 December 2012
Research
Liver cancer is one of the most common malignancies in the world and at the moment, there is no drug intervention effective for the treatment of liver tumours. Investigate the effect of N-acetylcysteine (NAC),...
Comparative Hepatology 2012 11:4
Published on: 4 December 2012
Research
After partial hepatectomy (PHx), the liver regeneration process terminates when the normal liver-mass/body-weight ratio of 2.5% has been re-established. To investigate the genetic regulation of the terminating...
Comparative Hepatology 2012 11:3
Published on: 20 November 2012
Research
This report presents a detailed description of hepatic architecture in 46 amphibian livers by light microscopy, and extensively discusses the phylogenetic viewpoint.
Comparative Hepatology 2012 11:2
Published on: 20 August 2012
Research
Type-2 Diabetes is a major health concern in the United States and other Westernized countries, with prevalence increasing yearly. There is a need to better model and predict adverse drug reactions, drug-induc...
Comparative Hepatology 2012 11:1
Published on: 23 April 2012
Research
Programmed cell death or apoptosis is an essential process for tissue homeostasis. Hepatocyte apoptosis is a common mechanism to many forms of liver disease. This study was undertaken to test the role of ILK i...
Comparative Hepatology 2011 10:11
Published on: 21 November 2011
Research
Non alcoholic steatohepatitis is hypothesised to develop via a mechanism involving fat accumulation and oxidative stress. The current study aimed to investigate if an increase in oxidative stress was associate...
Comparative Hepatology 2011 10:10
Published on: 14 November 2011
Case Report
Autoimmune liver diseases (AILDs) are common leading causes for liver cirrhosis and terminal stage of liver disease. They have variable prevalence among patients with liver disease and have two major clinical ...
Comparative Hepatology 2011 10:9
Published on: 12 September 2011
Research
Traditional assessment of drug-induced hepatotoxicity includes morphological examination of the liver and evaluation of liver enzyme activity in serum. The objective of the study was to determine the origin of...
Comparative Hepatology 2011 10:8
Published on: 17 August 2011
Research
The isolated perfused rat liver (IPRL) is a technique used in a wide range of liver studies. Typically livers are assessed at treatment end point. Techniques have been described to biopsy liver in the live rat...
Comparative Hepatology 2011 10:7
Published on: 8 August 2011
Case Report
Situs inversus totalis is is a congenital anomaly associated with various visceral abnormalities, but there is no data about the relationship between secondary biliary cirrhosis and that condition. We here pre...
Comparative Hepatology 2011 10:5
Published on: 3 August 2011
Research
Biliary atresia (BA) is an idiopathic inflammatory obliterative cholangiopathy of neonates, leading to progressive biliary cirrhosis. Hepatoportoenterostomy (Kasai procedure) can cure jaundice in 30% to 80% of...
Comparative Hepatology 2011 10:6
Published on: 3 August 2011
Research
To understand the complex and largely not well-understood apoptotic pathway and immune system evasion mechanisms in hepatitis C virus (HCV)-associated hepatocellular carcinoma (HCC) and HCV associated chronic ...
Comparative Hepatology 2011 10:4
Published on: 23 July 2011
Research
Ischemic pre- and postconditioning protects the liver against ischemia/reperfusion injuries. The aim of the present study was to examine how ischemic pre- and postconditioning affects gene expression of hypoxi...
Comparative Hepatology 2011 10:3
Published on: 19 July 2011
Research
Kupffer cells are well known macrophages of the liver, however, the developmental characteristics of Kupffer cells in mice are not well understood. To clarify this matter, the characteristics of Kupffer macrop...
Comparative Hepatology 2011 10:2
Published on: 12 July 2011
Research
Repeated apnoea events cause intermittent hypoxia (IH), which alters the function of various systems and produces free radicals and oxidative stress.
Comparative Hepatology 2011 10:1
Published on: 5 July 2011
Research
Under compromised biliary regeneration, transdifferentiation of hepatocytes into biliary epithelial cells (BEC) has been previously observed in rats, upon exposure to BEC-specific toxicant methylene dianiline ...
Comparative Hepatology 2010 9:9
Published on: 2 December 2010
Research
Proliferation of oval cells, the bipotent precursor cells of the liver, requires impeded proliferation and loss of hepatocytes as well as a specific micro-environment, provided by adjacent sinusoidal cells of ...
Comparative Hepatology 2010 9:8
Published on: 13 October 2010
Research
Hepatitis C virus (HCV) is a major cause of chronic hepatitis and a health problem affecting over 170 million people around the world. We previously studied transgenic mice that express HCV Core, Envelope 1 an...
Comparative Hepatology 2010 9:7
Published on: 20 August 2010
Research
ABCB4 functions as a phosphatidylcholine translocater, flipping phosphatidylcholine across hepatocyte canalicular membranes into biliary canaliculi. In people, ABCB4 gene mutations are associated with several ...
Comparative Hepatology 2010 9:6
Published on: 3 July 2010
Research
Temporal restriction of food availability entrains circadian behavioral and physiological rhythms in mammals by resetting peripheral oscillators. This entrainment underlies the activity of a timing system, dif...
Comparative Hepatology 2010 9:5
Published on: 23 February 2010
Research
The expression of Keratin 19 (K19) was reported in a subset of hepatocellular carcinomas (HCCs). K19 positive HCCs are associated with an increased malignancy compared to K19 negative HCCs. No suitable mouse m...
Comparative Hepatology 2010 9:4
Published on: 18 February 2010
Research
Perihepatitis is rare but consistently occurring extragenital manifestation of untreated Chlamydia trachomatis infection. Despite of possible liver involvement in generalized C. trachomatis infection, the ability...
Comparative Hepatology 2010 9:3
Published on: 28 January 2010
Research
Hemodynamic changes in the liver remnant following partial hepatectomy (PHx) have been suggested to be a primary stimulus in triggering liver regeneration. We hypothesized that it is the increased sinusoidal f...
Comparative Hepatology 2010 9:2
Published on: 20 January 2010
Research
Liver disease progression from chronic hepatitis C virus (HCV) infection to hepatocellular carcinoma (HCC) is associated with an imbalance between T-helper 1 and T-helper 2 cytokines. Evaluation of cytokines a...
Comparative Hepatology 2010 9:1
Published on: 5 January 2010
