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Comparative Hepatology

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  1. Content type: Review

    Alcoholic liver disease (ALD) is a significant cause of death and morbidity. Detection of liver fibrosis at an early stage could provide opportunities for more optimal management. Serum markers of liver fibros...

    Authors: Julie Parkes, Indra Neil Guha, Scott Harris, William MC Rosenberg and Paul J Roderick

    Citation: Comparative Hepatology 2012 11:5

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  2. Content type: Research

    Liver cancer is one of the most common malignancies in the world and at the moment, there is no drug intervention effective for the treatment of liver tumours. Investigate the effect of N-acetylcysteine (NAC),...

    Authors: Nelson Alexandre Kretzmann, Eduardo Chiela, Ursula Matte, Norma Marroni and Claudio Augusto Marroni

    Citation: Comparative Hepatology 2012 11:4

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  3. Content type: Research

    After partial hepatectomy (PHx), the liver regeneration process terminates when the normal liver-mass/body-weight ratio of 2.5% has been re-established. To investigate the genetic regulation of the terminating...

    Authors: Ingvild E Nygård, Kim E Mortensen, Jakob Hedegaard, Lene N Conley, Trine Kalstad, Christian Bendixen and Arthur Revhaug

    Citation: Comparative Hepatology 2012 11:3

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  4. Content type: Research

    Type-2 Diabetes is a major health concern in the United States and other Westernized countries, with prevalence increasing yearly. There is a need to better model and predict adverse drug reactions, drug-induc...

    Authors: Vijay R More, Xia Wen, Paul E Thomas, Lauren M Aleksunes and Angela L Slitt

    Citation: Comparative Hepatology 2012 11:1

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  5. Content type: Research

    Programmed cell death or apoptosis is an essential process for tissue homeostasis. Hepatocyte apoptosis is a common mechanism to many forms of liver disease. This study was undertaken to test the role of ILK i...

    Authors: Shashikiran Donthamsetty, Wendy M Mars, Anne Orr, Chuanyue Wu and George K Michalopoulos

    Citation: Comparative Hepatology 2011 10:11

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  6. Content type: Research

    Non alcoholic steatohepatitis is hypothesised to develop via a mechanism involving fat accumulation and oxidative stress. The current study aimed to investigate if an increase in oxidative stress was associate...

    Authors: Mile Janevski, Kiriakos N Antonas, Melanie J Sullivan-Gunn, Maree A McGlynn and Paul A Lewandowski

    Citation: Comparative Hepatology 2011 10:10

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  7. Content type: Research

    Traditional assessment of drug-induced hepatotoxicity includes morphological examination of the liver and evaluation of liver enzyme activity in serum. The objective of the study was to determine the origin of...

    Authors: Carmen Fuentealba, Monali Bera, Bart Jessen, Fred Sace, Greg J Stevens, Dusko Trajkovic, Amy H Yang and Winston Evering

    Citation: Comparative Hepatology 2011 10:8

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  8. Content type: Research

    The isolated perfused rat liver (IPRL) is a technique used in a wide range of liver studies. Typically livers are assessed at treatment end point. Techniques have been described to biopsy liver in the live rat...

    Authors: Anthony Rowe, Lillian Zhang, Azmena Hussain, Filip Braet and Iqbal Ramzan

    Citation: Comparative Hepatology 2011 10:7

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  9. Content type: Case Report

    Situs inversus totalis is is a congenital anomaly associated with various visceral abnormalities, but there is no data about the relationship between secondary biliary cirrhosis and that condition. We here pre...

    Authors: Hacı Mehmet Sökmen, Kamil Özdil, Turan Çalhan, Abdurrahman Şahin, Ebubekir Şenateş, Resul Kahraman, Adil Niğdelioğlu and Ebru Zemheri

    Citation: Comparative Hepatology 2011 10:5

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  10. Content type: Research

    Biliary atresia (BA) is an idiopathic inflammatory obliterative cholangiopathy of neonates, leading to progressive biliary cirrhosis. Hepatoportoenterostomy (Kasai procedure) can cure jaundice in 30% to 80% of...

    Authors: Keita Terui, Takeshi Saito, Tomoro Hishiki, Yoshiharu Sato, Tetsuya Mitsunaga and Hideo Yoshida

    Citation: Comparative Hepatology 2011 10:6

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  11. Content type: Research

    To understand the complex and largely not well-understood apoptotic pathway and immune system evasion mechanisms in hepatitis C virus (HCV)-associated hepatocellular carcinoma (HCC) and HCV associated chronic ...

    Authors: Abdel-Rahman N Zekri, Abeer A Bahnassy, Mohamed M Hafez, Zeinab K Hassan, Mahmoud Kamel, Samah A Loutfy, Ghada M Sherif, Abdel-Rahman El-Zayadi and Sayed S Daoud

    Citation: Comparative Hepatology 2011 10:4

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  12. Content type: Research

    Ischemic pre- and postconditioning protects the liver against ischemia/reperfusion injuries. The aim of the present study was to examine how ischemic pre- and postconditioning affects gene expression of hypoxi...

    Authors: Anders R Knudsen, Anne-Sofie Kannerup, Henning Grønbæk, Kasper J Andersen, Peter Funch-Jensen, Jan Frystyk, Allan Flyvbjerg and Frank V Mortensen

    Citation: Comparative Hepatology 2011 10:3

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  13. Content type: Research

    Kupffer cells are well known macrophages of the liver, however, the developmental characteristics of Kupffer cells in mice are not well understood. To clarify this matter, the characteristics of Kupffer macrop...

    Authors: Bryan G Lopez, Monica S Tsai, Janie L Baratta, Kenneth J Longmuir and Richard T Robertson

    Citation: Comparative Hepatology 2011 10:2

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  14. Content type: Research

    Under compromised biliary regeneration, transdifferentiation of hepatocytes into biliary epithelial cells (BEC) has been previously observed in rats, upon exposure to BEC-specific toxicant methylene dianiline ...

    Authors: Pallavi B Limaye, William C Bowen, Anne Orr, Udayan M Apte and George K Michalopoulos

    Citation: Comparative Hepatology 2010 9:9

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  15. Content type: Research

    Proliferation of oval cells, the bipotent precursor cells of the liver, requires impeded proliferation and loss of hepatocytes as well as a specific micro-environment, provided by adjacent sinusoidal cells of ...

    Authors: Elke Ueberham, Jan Böttger, Uwe Ueberham, Jens Grosche and Rolf Gebhardt

    Citation: Comparative Hepatology 2010 9:8

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  16. Content type: Research

    Hepatitis C virus (HCV) is a major cause of chronic hepatitis and a health problem affecting over 170 million people around the world. We previously studied transgenic mice that express HCV Core, Envelope 1 an...

    Authors: Turaya Naas, Masoud Ghorbani, Catalina Soare, Nicole Scherling, Rudy Muller, Peyman Ghorbani and Francisco Diaz-Mitoma

    Citation: Comparative Hepatology 2010 9:7

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  17. Content type: Research

    ABCB4 functions as a phosphatidylcholine translocater, flipping phosphatidylcholine across hepatocyte canalicular membranes into biliary canaliculi. In people, ABCB4 gene mutations are associated with several ...

    Authors: Katrina L Mealey, Jonathan D Minch, Stephen N White, Kevin R Snekvik and John S Mattoon

    Citation: Comparative Hepatology 2010 9:6

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  18. Content type: Research

    Temporal restriction of food availability entrains circadian behavioral and physiological rhythms in mammals by resetting peripheral oscillators. This entrainment underlies the activity of a timing system, dif...

    Authors: Mauricio Díaz-Muñoz, Olivia Vázquez-Martínez, Adrián Báez-Ruiz, Gema Martínez-Cabrera, María V Soto-Abraham, María C Ávila-Casado and Jorge Larriva-Sahd

    Citation: Comparative Hepatology 2010 9:5

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  19. Content type: Research

    The expression of Keratin 19 (K19) was reported in a subset of hepatocellular carcinomas (HCCs). K19 positive HCCs are associated with an increased malignancy compared to K19 negative HCCs. No suitable mouse m...

    Authors: Renee GHM van Sprundel, Ted SGAM van den Ingh, Valeer J Desmet, Azeam Katoonizadeh, Louis C Penning, Jan Rothuizen, Tania Roskams and Bart Spee

    Citation: Comparative Hepatology 2010 9:4

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  20. Content type: Research

    Perihepatitis is rare but consistently occurring extragenital manifestation of untreated Chlamydia trachomatis infection. Despite of possible liver involvement in generalized C. trachomatis infection, the ability...

    Authors: Yuriy K Bashmakov, Nailya A Zigangirova, Yulia P Pashko, Lidia N Kapotina and Ivan M Petyaev

    Citation: Comparative Hepatology 2010 9:3

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  21. Content type: Research

    Hemodynamic changes in the liver remnant following partial hepatectomy (PHx) have been suggested to be a primary stimulus in triggering liver regeneration. We hypothesized that it is the increased sinusoidal f...

    Authors: Kim E Mortensen, Lene N Conley, Ingvild Nygaard, Peter Sorenesen, Elin Mortensen, Christian Bendixen and Arthur Revhaug

    Citation: Comparative Hepatology 2010 9:2

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  22. Content type: Research

    Liver disease progression from chronic hepatitis C virus (HCV) infection to hepatocellular carcinoma (HCC) is associated with an imbalance between T-helper 1 and T-helper 2 cytokines. Evaluation of cytokines a...

    Authors: Abdel-Rahman N Zekri, Hanaa M Alam El-Din, Abeer A Bahnassy, Naglaa A Zayed, Waleed S Mohamed, Suzan H El-Masry, Sayed K Gouda and Gamal Esmat

    Citation: Comparative Hepatology 2010 9:1

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