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  1. Research

    Immunohistochemical study of the phenotypic change of the mesenchymal cells during portal tract maturation in normal and fibrous (ductal plate malformation) fetal liver

    In adult liver, the mesenchymal cells, portal fibroblasts and vascular smooth muscle cells can transdifferentiate into myofibroblasts, and are involved in portal fibrosis. Differential expression of markers, s...

    Julien Villeneuve, Fanny Pelluard-Nehme, Chantal Combe, Dominique Carles, Christine Chaponnier, Jean Ripoche, Charles Balabaud, Paulette Bioulac-Sage and Sébastien Lepreux

    Comparative Hepatology 2009 8:5

    Published on: 14 July 2009

  2. Research

    Comparison of different methods to obtain and store liver biopsies for molecular and histological research

    To minimize the necessary number of biopsies for molecular and histological research we evaluated different sampling techniques, fixation methods, and storage procedures for canine liver tissue. For addressing...

    Gaby Hoffmann, Jooske Ijzer, Bas Brinkhof, Baukje A Schotanus, Ted SGAM van den Ingh, Louis C Penning and Jan Rothuizen

    Comparative Hepatology 2009 8:3

    Published on: 8 July 2009

  3. Research

    Low affinity glucocorticoid binding site ligands as potential anti-fibrogenics

    Pregnane X receptor (PXR) agonists inhibit liver fibrosis. However, the rodent PXR activator pregnenolone 16α carbonitrile (PCN) blocks, in vitro, hepatic stellate cell-to-myofibroblast trans-differentiation and ...

    Carylyn J Marek, Karen Wallace, Elaine Durward, Matthew Koruth, Val Leel, Lucy J Leiper and Matthew C Wright

    Comparative Hepatology 2009 8:1

    Published on: 11 May 2009

  4. Research

    Phospholipase C beta 4 in mouse hepatocytes: Rhythmic expression and cellular distribution

    Circadian regulated physiological processes have been well documented in the mammalian liver. Phospholipases are important mediators of both cytoplasmic and nuclear signaling mechanisms in hepatocytes, and des...

    Brittany M Klein, Jane B Andrews, Barbra A Bannan, Ashley E Nazario-Toole, Travis C Jenkins, Kimberly D Christensen, Sorinel A Oprisan and Elizabeth L Meyer-Bernstein

    Comparative Hepatology 2008 7:8

    Published on: 28 October 2008

  5. Research

    A new parameter using serum lactate dehydrogenase and alanine aminotransferase level is useful for predicting the prognosis of patients at an early stage of acute liver injury: A retrospective study

    Although most patients with severe acute hepatitis are conservatively cured, some progress to acute liver failure (ALF) with a high rate of mortality. Based on the evidence that over-activation of macrophages,...

    Kazuhiro Kotoh, Munechika Enjoji, Masaki Kato, Motoyuki Kohjima, Makoto Nakamuta and Ryoichi Takayanagi

    Comparative Hepatology 2008 7:6

    Published on: 14 August 2008

  6. Research

    The influence of oxygen tension on the structure and function of isolated liver sinusoidal endothelial cells

    Liver sinusoidal endothelial cells (LSECs) are specialized scavenger cells, with crucial roles in maintaining hepatic and systemic homeostasis. Under normal physiological conditions, the oxygen tension encount...

    Inigo Martinez, Geir I Nedredal, Cristina I Øie, Alessandra Warren, Oddmund Johansen, David G Le Couteur and Bård Smedsrød

    Comparative Hepatology 2008 7:4

    Published on: 5 May 2008

  7. Case Report

    Sustained virological and biochemical responses to lamivudine and adefovir dipivoxil combination in a chronic hepatitis B infection despite mutations conferring resistance to both drugs

    Sequential monotherapies of nucleotide analogs used in chronic hepatitis B treatment can lead to the selection of a resistance mutation to each antiviral drug.

    Sylvie Larrat, Marie-Noëlle Hilleret, Raphaele Germi, Julien Lupo, Sandrine Nicod, Jean-Pierre Zarski, Jean-Marie Seigneurin and Patrice Morand

    Comparative Hepatology 2008 7:3

    Published on: 12 March 2008

  8. Case Report

    Over-expression of glutamine synthase in focal nodular hyperplasia (part 1): Early stages in the formation support the hypothesis of a focal hyper-arterialisation with venous (portal and hepatic) and biliary damage

    Most focal nodular hyperplasia (FNH) cases are diagnosed by chance. We studied a case of pre-FNH. We used glutamine synthase as an immunohistochemical marker for perivenous zones.

    Paulette Bioulac-Sage, Hervé Laumonier, Gaëlle Cubel, Jean Saric and Charles Balabaud

    Comparative Hepatology 2008 7:2

    Published on: 29 February 2008

  9. Research

    Plasma redox status is impaired in the portacaval shunted rat – the risk of the reduced antioxidant ability

    Portacaval shunting in rats produces a reduction of hepatic oxidant scavenging ability. Since this imbalance in hepatic oxidant/antioxidant homeostasis could coexist with systemic changes of oxidant stress/ant...

    Maria-Angeles Aller, Maria-Inmaculada García-Fernández, Fernando Sánchez-Patán, Luis Santín, José Rioja, Raquel Anchuelo, Jaime Arias and Jorge-Luis Arias

    Comparative Hepatology 2008 7:1

    Published on: 5 February 2008

  10. Research

    CIDE-A is expressed in liver of old mice and in type 2 diabetic mouse liver exhibiting steatosis

    Increased levels of circulating fatty acids caused by insulin resistance and increased adipocyte lipolysis can accumulate within the liver resulting in steatosis. This steatosis sensitizes the liver to inflamm...

    Bruce Kelder, Keith Boyce, Andres Kriete, Ryan Clark, Darlene E Berryman, Sheila Nagatomi, Edward O List, Mark Braughler and John J Kopchick

    Comparative Hepatology 2007 6:4

    Published on: 1 May 2007

  11. Research

    Effects of lamivudine on serum albumin levels correlate with pretreatment HBV-DNA levels in cirrhotic patients

    Lamivudine treatment has been recently demonstrated to increase the serum albumin levels in cirrhotic patients with hepatitis B virus (HBV) infection, but the precise mechanism remains unclear. We hypothesized...

    Makoto Nakamuta, Kazuhiro Kotoh, Munechika Enjoji, Eiji Kajiwara, Junya Shimono, Akihide Masumoto, Toshihiro Maruyama, Norihiro Furusyo, Hideyuki Nomura, Hironori Sakai, Kazuhiro Takahashi, Koichi Azuma, Shinji Shimoda, Yuichi Tanabe and Jun Hayashi

    Comparative Hepatology 2007 6:3

    Published on: 1 May 2007

  12. Research

    Interactions Between Estrogen- and Ah-Receptor Signalling Pathways in Primary Culture of Salmon Hepatocytes Exposed to Nonylphenol and 3,3',4,4'-Tetrachlorobiphenyl (Congener 77)

    The estrogenic and xenobiotic biotransformation gene expressions are receptor-mediated processes that are ligand structure-dependent interactions with estrogen-receptor (ER) and aryl hydrocarbon receptor (AhR)...

    Anne S Mortensen and Augustine Arukwe

    Comparative Hepatology 2007 6:2

    Published on: 13 April 2007

  13. Research

    TGF-β dependent regulation of oxygen radicals during transdifferentiation of activated hepatic stellate cells to myofibroblastoid cells

    The activation of hepatic stellate cells (HSCs) plays a pivotal role during liver injury because the resulting myofibroblasts (MFBs) are mainly responsible for connective tissue re-assembly. MFBs represent the...

    Verena Proell, Irene Carmona-Cuenca, Miguel M Murillo, Heidemarie Huber, Isabel Fabregat and Wolfgang Mikulits

    Comparative Hepatology 2007 6:1

    Published on: 20 February 2007

  14. Research

    Comparison of tissue pressure and ablation time between the LeVeen and cool-tip needle methods

    Radio frequency ablation (RFA) has been accepted clinically as a useful local treatment for hepatocellular carcinoma (HCC). However, intrahepatic recurrence after RFA has been reported which might be attributa...

    Makoto Nakamuta, Motoyuki Kohjima, Shusuke Morizono, Tsuyoshi Yoshimoto, Yuzuru Miyagi, Hironori Sakai, Munechika Enjoji and Kazuhiro Kotoh

    Comparative Hepatology 2006 5:10

    Published on: 21 December 2006

  15. Research

    Sensitivity to endothelin-1 is decreased in isolated livers of endothelial constitutive nitric oxide synthase knockout mice

    Hepatic sinusoidal resistance is regulated by vasoactive factors including endothelin-1 (ET-1) and nitric oxide (NO). In the absence of NO, vasoconstrictor response to endothelin is expected to predominate. Th...

    Andrea De Gottardi, Erwin Biecker, Abraham Koshy, Dieter Bohler, Sidney Shaw, Hans Sägesser and Jürg Reichen

    Comparative Hepatology 2006 5:9

    Published on: 5 December 2006

  16. Research

    Feeding and fasting controls liver expression of a regulator of G protein signaling (Rgs16) in periportal hepatocytes

    Heterotrimeric G protein signaling in liver helps maintain carbohydrate and lipid homeostasis. G protein signaling is activated by binding of extracellular ligands to G protein coupled receptors and inhibited ...

    Jie Huang, Victor Pashkov, Deborah M Kurrasch, Kan Yu, Stephen J Gold and Thomas M Wilkie

    Comparative Hepatology 2006 5:8

    Published on: 23 November 2006

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