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Comparative Hepatology


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  1. Content type: Research

    In adult liver, the mesenchymal cells, portal fibroblasts and vascular smooth muscle cells can transdifferentiate into myofibroblasts, and are involved in portal fibrosis. Differential expression of markers, s...

    Authors: Julien Villeneuve, Fanny Pelluard-Nehme, Chantal Combe, Dominique Carles, Christine Chaponnier, Jean Ripoche, Charles Balabaud, Paulette Bioulac-Sage and Sébastien Lepreux

    Citation: Comparative Hepatology 2009 8:5

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  2. Content type: Research

    To minimize the necessary number of biopsies for molecular and histological research we evaluated different sampling techniques, fixation methods, and storage procedures for canine liver tissue. For addressing...

    Authors: Gaby Hoffmann, Jooske Ijzer, Bas Brinkhof, Baukje A Schotanus, Ted SGAM van den Ingh, Louis C Penning and Jan Rothuizen

    Citation: Comparative Hepatology 2009 8:3

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  3. Content type: Research

    Pregnane X receptor (PXR) agonists inhibit liver fibrosis. However, the rodent PXR activator pregnenolone 16α carbonitrile (PCN) blocks, in vitro, hepatic stellate cell-to-myofibroblast trans-differentiation and ...

    Authors: Carylyn J Marek, Karen Wallace, Elaine Durward, Matthew Koruth, Val Leel, Lucy J Leiper and Matthew C Wright

    Citation: Comparative Hepatology 2009 8:1

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  4. Content type: Research

    Circadian regulated physiological processes have been well documented in the mammalian liver. Phospholipases are important mediators of both cytoplasmic and nuclear signaling mechanisms in hepatocytes, and des...

    Authors: Brittany M Klein, Jane B Andrews, Barbra A Bannan, Ashley E Nazario-Toole, Travis C Jenkins, Kimberly D Christensen, Sorinel A Oprisan and Elizabeth L Meyer-Bernstein

    Citation: Comparative Hepatology 2008 7:8

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  5. Content type: Research

    A novel transparent stock of medaka (Oryzias latipes; STII), recessive for all pigments found in chromatophores, permits transcutaneous imaging of internal organs and tissues in living individuals. Findings prese...

    Authors: Ron C Hardman, Seth W Kullman and David E Hinton

    Citation: Comparative Hepatology 2008 7:7

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  6. Content type: Research

    Although most patients with severe acute hepatitis are conservatively cured, some progress to acute liver failure (ALF) with a high rate of mortality. Based on the evidence that over-activation of macrophages,...

    Authors: Kazuhiro Kotoh, Munechika Enjoji, Masaki Kato, Motoyuki Kohjima, Makoto Nakamuta and Ryoichi Takayanagi

    Citation: Comparative Hepatology 2008 7:6

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  7. Content type: Research

    In a previous study we confirmed that canine hepatic lipogranuloma, defined as lesions consisting of small round cells which contain lipid vacuoles and brown pigments in their cytoplasm, was an assembly of Kup...

    Authors: Kaori Isobe, Hiroyuki Nakayama and Koji Uetsuka

    Citation: Comparative Hepatology 2008 7:5

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  8. Content type: Research

    Liver sinusoidal endothelial cells (LSECs) are specialized scavenger cells, with crucial roles in maintaining hepatic and systemic homeostasis. Under normal physiological conditions, the oxygen tension encount...

    Authors: Inigo Martinez, Geir I Nedredal, Cristina I Øie, Alessandra Warren, Oddmund Johansen, David G Le Couteur and Bård Smedsrød

    Citation: Comparative Hepatology 2008 7:4

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  9. Content type: Case Report

    Sequential monotherapies of nucleotide analogs used in chronic hepatitis B treatment can lead to the selection of a resistance mutation to each antiviral drug.

    Authors: Sylvie Larrat, Marie-Noëlle Hilleret, Raphaele Germi, Julien Lupo, Sandrine Nicod, Jean-Pierre Zarski, Jean-Marie Seigneurin and Patrice Morand

    Citation: Comparative Hepatology 2008 7:3

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  10. Content type: Case Report

    Most focal nodular hyperplasia (FNH) cases are diagnosed by chance. We studied a case of pre-FNH. We used glutamine synthase as an immunohistochemical marker for perivenous zones.

    Authors: Paulette Bioulac-Sage, Hervé Laumonier, Gaëlle Cubel, Jean Saric and Charles Balabaud

    Citation: Comparative Hepatology 2008 7:2

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  11. Content type: Research

    Portacaval shunting in rats produces a reduction of hepatic oxidant scavenging ability. Since this imbalance in hepatic oxidant/antioxidant homeostasis could coexist with systemic changes of oxidant stress/ant...

    Authors: Maria-Angeles Aller, Maria-Inmaculada García-Fernández, Fernando Sánchez-Patán, Luis Santín, José Rioja, Raquel Anchuelo, Jaime Arias and Jorge-Luis Arias

    Citation: Comparative Hepatology 2008 7:1

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  12. Content type: Research

    The availability of non-rodent animal models for human cirrhosis is limited. We investigated whether privately-owned dogs (Canis familiaris) are potential model animals for liver disease focusing on regenerative ...

    Authors: Bart Spee, Brigitte Arends, Ted SGAM van den Ingh, Tania Roskams, Jan Rothuizen and Louis C Penning

    Citation: Comparative Hepatology 2007 6:8

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  13. Content type: Research

    Several highly proliferative human cells transiently activate telomerase, a ribonucleoprotein with reverse transcriptase activity, to counterbalance replication-associated telomere erosion and to increase stre...

    Authors: Henning Wege, Anett Müller, Lars Müller, Susan Petri, Jörg Petersen and Christian Hillert

    Citation: Comparative Hepatology 2007 6:6

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  14. Content type: Research

    Increased levels of circulating fatty acids caused by insulin resistance and increased adipocyte lipolysis can accumulate within the liver resulting in steatosis. This steatosis sensitizes the liver to inflamm...

    Authors: Bruce Kelder, Keith Boyce, Andres Kriete, Ryan Clark, Darlene E Berryman, Sheila Nagatomi, Edward O List, Mark Braughler and John J Kopchick

    Citation: Comparative Hepatology 2007 6:4

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  15. Content type: Research

    Lamivudine treatment has been recently demonstrated to increase the serum albumin levels in cirrhotic patients with hepatitis B virus (HBV) infection, but the precise mechanism remains unclear. We hypothesized...

    Authors: Makoto Nakamuta, Kazuhiro Kotoh, Munechika Enjoji, Eiji Kajiwara, Junya Shimono, Akihide Masumoto, Toshihiro Maruyama, Norihiro Furusyo, Hideyuki Nomura, Hironori Sakai, Kazuhiro Takahashi, Koichi Azuma, Shinji Shimoda, Yuichi Tanabe and Jun Hayashi

    Citation: Comparative Hepatology 2007 6:3

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  16. Content type: Research

    The estrogenic and xenobiotic biotransformation gene expressions are receptor-mediated processes that are ligand structure-dependent interactions with estrogen-receptor (ER) and aryl hydrocarbon receptor (AhR)...

    Authors: Anne S Mortensen and Augustine Arukwe

    Citation: Comparative Hepatology 2007 6:2

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  17. Content type: Research

    The activation of hepatic stellate cells (HSCs) plays a pivotal role during liver injury because the resulting myofibroblasts (MFBs) are mainly responsible for connective tissue re-assembly. MFBs represent the...

    Authors: Verena Proell, Irene Carmona-Cuenca, Miguel M Murillo, Heidemarie Huber, Isabel Fabregat and Wolfgang Mikulits

    Citation: Comparative Hepatology 2007 6:1

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  18. Content type: Research

    Radio frequency ablation (RFA) has been accepted clinically as a useful local treatment for hepatocellular carcinoma (HCC). However, intrahepatic recurrence after RFA has been reported which might be attributa...

    Authors: Makoto Nakamuta, Motoyuki Kohjima, Shusuke Morizono, Tsuyoshi Yoshimoto, Yuzuru Miyagi, Hironori Sakai, Munechika Enjoji and Kazuhiro Kotoh

    Citation: Comparative Hepatology 2006 5:10

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  19. Content type: Research

    Hepatic sinusoidal resistance is regulated by vasoactive factors including endothelin-1 (ET-1) and nitric oxide (NO). In the absence of NO, vasoconstrictor response to endothelin is expected to predominate. Th...

    Authors: Andrea De Gottardi, Erwin Biecker, Abraham Koshy, Dieter Bohler, Sidney Shaw, Hans Sägesser and Jürg Reichen

    Citation: Comparative Hepatology 2006 5:9

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  20. Content type: Research

    Heterotrimeric G protein signaling in liver helps maintain carbohydrate and lipid homeostasis. G protein signaling is activated by binding of extracellular ligands to G protein coupled receptors and inhibited ...

    Authors: Jie Huang, Victor Pashkov, Deborah M Kurrasch, Kan Yu, Stephen J Gold and Thomas M Wilkie

    Citation: Comparative Hepatology 2006 5:8

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