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  1. Hepatic fibrosis is a common outcome of hepatic injury in both man and dog. Activated fibroblasts which develop myofibroblastic characteristics play an essential role in hepatic fibrogenesis, and are comprised...

    Authors: Jooske IJzer, Tania Roskams, Ronald F Molenbeek, Ton Ultee, Louis C Penning, Jan Rothuizen and Ted SGAM van den Ingh
    Citation: Comparative Hepatology 2006 5:7
  2. The transcriptome is the mRNA transcript pool in a cell, organ or tissue with the liver transcriptome being amongst the most complex of any organ. Functional genomics methodologies are now being widely utilize...

    Authors: Nicholas A Shackel, Devanshi Seth, Paul S Haber, Mark D Gorrell and Geoffrey W McCaughan
    Citation: Comparative Hepatology 2006 5:6
  3. In liver injury, the pool of hepatic stellate cell (HSC) increases and produces extracellular matrix proteins, decreasing during the resolution of fibrosis. The profibrogenic role of endothelin-1 (ET-1) in liv...

    Authors: Masahiko Koda, Michael Bauer, Anja Krebs, Eckhart G Hahn, Detlef Schuppan and Yoshikazu Murawaki
    Citation: Comparative Hepatology 2006 5:5
  4. Information about genotypes and associated risk factors in hepatitis C virus (HCV) infected patients in Iran is limited. The aim of this study was to identify the HCV genotypes and associated risk factors in a...

    Authors: Ali Kabir, Seyed-Moayed Alavian and Hussein Keyvani
    Citation: Comparative Hepatology 2006 5:4
  5. In patients with cirrhosis, infection is frequent and a leading cause of death. This is secondary to various immunologic abnormalities in both the innate and the adaptive immune system. However, it remains unc...

    Authors: Susanne Schouw Nielsen, Thorbjørn Grøfte, Niels Tygstrup and Hendrik Vilstrup
    Citation: Comparative Hepatology 2006 5:3
  6. Alpha-fetoprotein (AFP) expression can resume in the adult liver under pathophysiological conditions. Orphan nuclear receptors were supposed to regulate AFP gene expression, in vitro. We were interested to study ...

    Authors: Volker Meier, Kyrylo Tron, Danko Batusic, Abderrahim Elmaouhoub and Giuliano Ramadori
    Citation: Comparative Hepatology 2006 5:2
  7. Prolonged adefovir therapy exposes to the emergence of adefovir resistant hepatitis B virus mutants. Initial reports of the rtN236T mutation showed preserved sensitivity to lamivudine; however, complex mutatio...

    Authors: Vlad Ratziu, Vincent Thibault, Yves Benhamou and Thierry Poynard
    Citation: Comparative Hepatology 2006 5:1
  8. Biopsy is the usual gold standard for liver steatosis assessment. The aim of this study was to identify a panel of biomarkers (SteatoTest), with sufficient predictive values, for the non-invasive diagnosis of ...

    Authors: Thierry Poynard, Vlad Ratziu, Sylvie Naveau, Dominique Thabut, Frederic Charlotte, Djamila Messous, Dominique Capron, Annie Abella, Julien Massard, Yen Ngo, Mona Munteanu, Anne Mercadier, Michael Manns and Janice Albrecht
    Citation: Comparative Hepatology 2005 4:10
  9. Pegylated interferon given for 24 or 48 weeks constitutes the most effective initial therapy for the treatment of chronic hepatitis C. It has been shown that viral load at week 2 appears the best time for pred...

    Authors: Denis Ouzan, Hacène Khiri, Guillaume Pénaranda, Hélène Joly and Philippe Halfon
    Citation: Comparative Hepatology 2005 4:9
  10. Substantial recent experimental evidence has demonstrated the existence of reciprocal interactions between the microvascular bed of a specific organ and intravascular metastatic tumor cells through expression ...

    Authors: Hui Helen Wang, Hongming Qiu, Ke Qi and F William Orr
    Citation: Comparative Hepatology 2005 4:8
  11. We analyzed two spontaneous dog diseases characterized by subnormal portal perfusion and reduced liver growth: (i) congenital portosystemic shunts (CPSS) without fibrosis and (ii) primary portal vein hypoplasi...

    Authors: Bart Spee, Louis C Penning, Ted SGAM van den Ingh, Brigitte Arends, Jooske IJzer, Frederik J van Sluijs and Jan Rothuizen
    Citation: Comparative Hepatology 2005 4:7
  12. In patients with chronic hepatitis C virus, liver biopsy is the gold standard for assessing liver disease stage; nevertheless, it is prone to complications, some of them serious. Non-invasive methods have been...

    Authors: Philippe Halfon, Marc Bourlière, Guillaume Pénaranda, Romaric Deydier, Christophe Renou, Danielle Botta-Fridlund, Albert Tran, Isabelle Portal, Isabelle Allemand, Alessandra Rosenthal-Allieri and Denis Ouzan
    Citation: Comparative Hepatology 2005 4:6
  13. The presence of a hypervascular nodule in a patient with cirrhosis is highly suggestive of a hepatocellular carcinoma.

    Authors: António Sá Cunha, Jean-Frédéric Blanc, Hervé Trillaud, Victor De Ledinghen, Charles Balabaud and Paulette Bioulac-Sage
    Citation: Comparative Hepatology 2005 4:5
  14. DT diaphorase (DTD; NAD(P)H:quinone oxidoreductase; EC 1.6.99.2) catalyses the two electron reduction of quinones, thus preventing redox cycling and consequently quinone dependent production of reactive oxygen...

    Authors: Joachim Sturve, Eiríkur Stephensen and Lars Förlin
    Citation: Comparative Hepatology 2005 4:4
  15. The role of copper accumulation in the onset of hepatitis is still unclear. Therefore, we investigated a spontaneous disease model of primary copper-toxicosis in Doberman pinschers so to gain insights into the...

    Authors: Bart Spee, Paul JJ Mandigers, Brigitte Arends, Peter Bode, Ted SGAM van den Ingh, Gaby Hoffmann, Jan Rothuizen and Louis C Penning
    Citation: Comparative Hepatology 2005 4:3
  16. Xenoestrogens and antifungal azoles probably share a common route of metabolism, through hepatic cytochrome P450 (CYP) enzymes. Chemical interactions with metabolic pathways may affect clearance of both xenobi...

    Authors: Linda Hasselberg, Bjørn E Grøsvik, Anders Goksøyr and Malin C Celander
    Citation: Comparative Hepatology 2005 4:2
  17. During the early stages of systemic inflammation, the liver integrity is compromised by microcirculatory disturbances and subsequent hepatocellular injury. Little is known about the relationship between the he...

    Authors: Christian Wunder, Robert W Brock, Alfons Krug, Norbert Roewer and Otto Eichelbrönner
    Citation: Comparative Hepatology 2005 4:1
  18. The cytokine leukemia inhibitory factor (LIF) mediates its biological effects through binding to its high affinity receptor made of the low-affinity LIF receptor subunit gp190 (LIF-R) and the gp130 subunit. LI...

    Authors: Toru Hisaka, Alexis Desmoulière, Jean-Luc Taupin, Sophie Daburon, Véronique Neaud, Nathalie Senant, Jean-Frédéric Blanc, Jean-François Moreau and Jean Rosenbaum
    Citation: Comparative Hepatology 2004 3:10
  19. Hepatocellular carcinoma (HCC) is one of the most worldwide frequent primary carcinomas resulting in the death of many cirrhotic patients. Unfortunately, the molecular mechanisms of this cancer are not well un...

    Authors: Sacha Y Boomkens, Bart Spee, Jooske IJzer, Ronald Kisjes, Herman F Egberink, Ted SGAM van den Ingh, Jan Rothuizen and Louis C Penning
    Citation: Comparative Hepatology 2004 3:9
  20. Recent studies strongly suggest that due to the limitations and risks of biopsy, as well as the improvement of the diagnostic accuracy of biochemical markers, liver biopsy should no longer be considered mandat...

    Authors: Thierry Poynard, Françoise Imbert-Bismut, Mona Munteanu, Djamila Messous, Robert P Myers, Dominique Thabut, Vlad Ratziu, Anne Mercadier, Yves Benhamou and Bernard Hainque
    Citation: Comparative Hepatology 2004 3:8
  21. Shear stress forces acting on liver sinusoidal endothelial cells following resection have been noted as a possible trigger in the early stages of hepatic regeneration. Thus, the morphology and gene expression ...

    Authors: Filip Braet, Maria Shleper, Melia Paizi, Sergey Brodsky, Natalia Kopeiko, Nitzan Resnick and Gadi Spira
    Citation: Comparative Hepatology 2004 3:7
  22. It has been documented that nitric oxide (NO) donor sodium nitroprusside (SNP) and authentic peroxynitrite are capable of promoting apoptosis in a number of different cell types. Various endonucleases have bee...

    Authors: Gordana Kocic, Dusica Pavlovic, Radmila Pavlovic, Goran Nikolic, Tatjana Cvetkovic, Ivana Stojanovic, Tatjana Jevtovic, Radivoj Kocic and Dusan Sokolovic
    Citation: Comparative Hepatology 2004 3:6
  23. Keratins are members of the intermediate filaments (IFs) proteins, which constitute one of the three major cytoskeletal protein families. In hepatocytes, keratin 8 and 18 (K8/18) are believed to play a protect...

    Authors: Michel Fausther, Louis Villeneuve and Monique Cadrin
    Citation: Comparative Hepatology 2004 3:5
  24. The liver sinusoidal endothelial cells (LSEC) and Kupffer cells constitute the most powerful scavenger system in the body. Various waste macromolecules, continuously released from tissues in large quantities a...

    Authors: Kjetil H Elvevold, Geir I Nedredal, Arthur Revhaug and Bård Smedsrød
    Citation: Comparative Hepatology 2004 3:4
  25. Biochemical marker combinations, including α2-macroglobulin, haptoglobin, apolipoprotein A1, γ-glutamyl transpeptidase, and total bilirubin (all part of FibroTest) plus alanine aminotransferase (all part of ActiT...

    Authors: Mona Munteanu, Djamila Messous, Dominique Thabut, Françoise Imbert-Bismut, Mathieu Jouys, Julien Massard, Annie Piton, Luminita Bonyhay, Vlad Ratziu, Bernard Hainque and Thierry Poynard
    Citation: Comparative Hepatology 2004 3:3
  26. In the fish liver, the synthesis of egg yolk protein precursor vitellogenin (VTG) is under control of the estrogen receptor alpha (ERα). Environmental contaminants such as 2,3,7,8-tetrachloro-dibenzo-p-dioxin (TC...

    Authors: Vahid Bemanian, Rune Male and Anders Goksøyr
    Citation: Comparative Hepatology 2004 3:2
  27. A limitation for investigating the pathophysiological role of neutrophils in vivo is the lack of a reliable biomarker for neutrophil cytotoxicity in the liver. Therefore, we investigated if immunohistochemical de...

    Authors: Jaspreet S Gujral, Jack A Hinson and Hartmut Jaeschke
    Citation: Comparative Hepatology 2004 3(Suppl 1):S48

    This article is part of a Supplement: Volume 3 Supplement 1

  28. Heme oxygenase-1 (HO-1) is a stress response enzyme, which catalyses the breakdown of heme into biliverdin-IX alpha, carbon monoxide and ferrous iron. Under situations of oxidative stress, heat stress, ischemi...

    Authors: Robert B Dorman, Mary Lynn Bajt, Anwar Farhood, January Mayes and Hartmut Jaeschke
    Citation: Comparative Hepatology 2004 3(Suppl 1):S42

    This article is part of a Supplement: Volume 3 Supplement 1

  29. Iron is both essential and toxic for cells and impaired iron homeostasis has been shown to cause or potentiate various forms of liver injury. Research in our laboratory suggests that iron also plays a pivotal ...

    Authors: Shigang Xiong, Hongyun She and Hidekazu Tsukamoto
    Citation: Comparative Hepatology 2004 3(Suppl 1):S36

    This article is part of a Supplement: Volume 3 Supplement 1

  30. Authors: Mikio Yanase, Hitoshi Ikeda, Atsushi Matsui, Eisei Noiri, Tomoaki Tomiya, Masahiro Arai, Yukiko Inoue, Kazuaki Tejima, Kayo Nagashima, Takako Nishikawa, Satoshi Kimura, Kenji Fujiwara, Marcos Rojkind and Itsuro Ogata
    Citation: Comparative Hepatology 2004 3(Suppl 1):S21

    This article is part of a Supplement: Volume 3 Supplement 1

  31. Authors: Mutsunori Fujiwara, Kazuhiko Besshi, Tamiko Takemura, Yukiko Ito, Takeshi Tsujino, Michiko Yamagata, Nobuyuki Minagawa, Ryo Nakata, Michiyasu Yoshitsugu, Yoshihisa Kato, Masashi Ihori, Isao Okayasu, Haruki Senoo and Kenjiro Wake
    Citation: Comparative Hepatology 2004 3(Suppl 1):S15

    This article is part of a Supplement: Volume 3 Supplement 1

  32. To investigate whether or not hepatic stellate cells can form intercellular junctions with each other, we cultured human stellate cells (LI90) on different kinds of substrata. Intercellular junctions were dete...

    Authors: Katsuyuki Imai, Mitsuru Sato, Takeya Sato, Naosuke Kojima, Mitsutaka Miura, Nobuyo Higashi, Da-Ren Wang, Shinsuke Suzuki and Haruki Senoo
    Citation: Comparative Hepatology 2004 3(Suppl 1):S13

    This article is part of a Supplement: Volume 3 Supplement 1

  33. Apoptosis of hepatic stellate cells (HSC) has previously been shown to occur during spontaneous resolution of experimental liver fibrosis. TIMP-1 has also been shown to have a key role because of its ability t...

    Authors: Frank Murphy, Julian Waung, Jane Collins, Michael JP Arthur, Hideaki Nagase, Derek Mann, R Christopher Benyon and John P Iredale
    Citation: Comparative Hepatology 2004 3(Suppl 1):S8

    This article is part of a Supplement: Volume 3 Supplement 1

  34. HSCs showed myofibroblast-like shapes when cultured on polystyrene surface or on type I collagen-coated surface, whereas HSCs cultured on type I collagen gel were induced to elongate cellular processes, sugges...

    Authors: Mitsuru Sato, Takeya Sato, Naosuke Kojima, Katsuyuki Imai, Nobuyo Higashi, Da-Ren Wang and Haruki Senoo
    Citation: Comparative Hepatology 2004 3(Suppl 1):S4

    This article is part of a Supplement: Volume 3 Supplement 1