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Table 1 Overview of the canine histological classification.

From: Keratin 19 marks poor differentiation and a more aggressive behaviour in canine and human hepatocellular tumours

Groups K19 expression Grading
0 to 3
Staging
0 to 2
K7 expression Glypican-3 expression HepPar-1 expression
Normal liver
(n = 5)
0% 0 0 0% 0% 100%
Nodular hyperplasia (n = 4) 0% 0 0 0% 0% 100%
Hepatocellular tumour K19 negative (n = 30) 0-5% 1 (n = 24)
2 (n = 6)
0 0% (n = 29)
5% (n = 1)
0% 50-75% (n = 2)
90-100% (n = 28)
Hepatocellular tumour K19 positive (n = 4) 10-90% 3 1 - 2 0% (n = 2)
5% (n = 2)
30-100% 0%
  1. Grouping based on histology and K19 expression in hepatocytes compared with the results of the grading, staging, and clinicopathological markers