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Table 1 Overview of the canine histological classification.

From: Keratin 19 marks poor differentiation and a more aggressive behaviour in canine and human hepatocellular tumours

Groups

K19 expression

Grading

0 to 3

Staging

0 to 2

K7 expression

Glypican-3 expression

HepPar-1 expression

Normal liver

(n = 5)

0%

0

0

0%

0%

100%

Nodular hyperplasia (n = 4)

0%

0

0

0%

0%

100%

Hepatocellular tumour K19 negative (n = 30)

0-5%

1 (n = 24)

2 (n = 6)

0

0% (n = 29)

5% (n = 1)

0%

50-75% (n = 2)

90-100% (n = 28)

Hepatocellular tumour K19 positive (n = 4)

10-90%

3

1 - 2

0% (n = 2)

5% (n = 2)

30-100%

0%

  1. Grouping based on histology and K19 expression in hepatocytes compared with the results of the grading, staging, and clinicopathological markers