Histological evaluation of Doberman hepatitis. (A) Hepatitis characterised by accumulation of pigmented granules (probably copper) in hepatocytes, and inflammation with lymphocytes and pigmented (probably copper) macrophages. HE staining. (B) Centrolobular accumulation of copper in hepatocytes and band of fibrous tissue with inflammatory cells and copper-laden macrophages. Rubeanic acid staining. P = Portal area, CV = Central vein area.