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Table 2 Integrated database, with predictive values for significant hepatic fibrosis according to METAVIR conversion cut offs. Derived from published studies.

From: Overview of the diagnostic value of biochemical markers of liver fibrosis (FibroTest, HCV FibroSure) and necrosis (ActiTest) in patients with chronic hepatitis C

Integrated database Patient number Marker Stage/Prevalence AUROC (SE) Cut off used for METAVIR stages conversion Sensitivity Specificity Negative predictive value Positive predictive value
With Blood Donors 1,570 FibroTest F2F3F4/0.31 0.83 (0.01) 0.21 0.92 0.55 0.94 0.48
      0.27 0.87 0.62 0.92 0.51
      0.31 0.84 0.68 0.91 0.54
      0.48 0.68 0.81 0.85 0.61
      0.58 0.56 0.87 0.82 0.67
      0.72 0.38 0.95 0.77 0.76
      0.74 0.35 0.95 0.76 0.76
      0.75 0.33 0.96 0.76 0.78
Without blood donors 1,270 FibroTest F2F3F4/0.38 0.78 (0.01) 0.21 0.92 0.41 0.89 0.49
      0.27 0.87 0.48 0.86 0.51
      0.31 0.84 0.55 0.85 0.54
      0.48 0.68 0.73 0.79 0.61
      0.58 0.56 0.83 0.75 0.67
      0.72 0.38 0.95 0.70 0.76
      0.74 0.35 0.93 0.70 0.76
      0.75 0.33 0.94 0.69 0.78