Overview of the diagnostic value of biochemical markers of liver fibrosis (FibroTest, HCV FibroSure) and necrosis (ActiTest) in patients with chronic hepatitis C

Table 2 Integrated database, with predictive values for significant hepatic fibrosis according to METAVIR conversion cut offs. Derived from published studies.

Integrated database	Patient number	Marker	Stage/Prevalence	AUROC (SE)	Cut off used for METAVIR stages conversion	Sensitivity	Specificity	Negative predictive value	Positive predictive value
With Blood Donors	1,570	FibroTest	F2F3F4/0.31	0.83 (0.01)	0.21	0.92	0.55	0.94	0.48
					0.27	0.87	0.62	0.92	0.51
					0.31	0.84	0.68	0.91	0.54
					0.48	0.68	0.81	0.85	0.61
					0.58	0.56	0.87	0.82	0.67
					0.72	0.38	0.95	0.77	0.76
					0.74	0.35	0.95	0.76	0.76
					0.75	0.33	0.96	0.76	0.78
Without blood donors	1,270	FibroTest	F2F3F4/0.38	0.78 (0.01)	0.21	0.92	0.41	0.89	0.49
					0.27	0.87	0.48	0.86	0.51
					0.31	0.84	0.55	0.85	0.54
					0.48	0.68	0.73	0.79	0.61
					0.58	0.56	0.83	0.75	0.67
					0.72	0.38	0.95	0.70	0.76
					0.74	0.35	0.93	0.70	0.76
					0.75	0.33	0.94	0.69	0.78