Scanning electron micrographs of liver periportal sinusoids. (a) control, (b-f) following partial hepatectomy; control liver (a) demonstrates an intact fenestrated wall (arrow) and undisrupted bordering parenchymal cells (Pc). Inset depicts fenestrae (arrowhead). (b) Numerous gaps (arrow) are observed as early as ten minutes after PHx. Inset shows a detailed image of gaps (arrow) and fenestrae (arrowhead). (c) 24 hrs after PHx, gaps (arrow) are still present. Note the protruding microvilli from the underlying parenchymal cell surface (arrowhead). Small structures (*), probably platelets, could be noticed adhering to endothelial wall. 72 hrs (d) and 168 hrs (e) after PHx, depicting features similar to those seen in (c). (f) Ten days after PHx an intact endothelial lining (arrow) and fenestrae (arrowhead) could be observed. Scale bars: 2 μm; Insets: 0.5 μm.