Figure 3
From: Pit cells exclusively kill P815 tumor cells by the perforin/granzyme pathway
Model of hepatic NK cell-mediated tumor cell killing. For explanation: see text. The blocked FasL pathway is indicated in gray. Dashed lines indicate hypothetical relations. FADD, Fas-associated death domain factor; FasL, Fas ligand; LFA-1, leukocyte function associated molecule-1; G, granzyme B; HA-R, hyaluronan receptor; ICAM-1, intercellular adhesion molecule-1; M6P-R, mannose 6 phosphate receptor (cation-independent); P, perforin; PI-9, protease inhibitor 9; S, serglycin; sFas, soluble Fas. (From reference 8, with permission.)