Figure 1From: 3-D structure of extracellular matrix regulates gene expression in cultured hepatic stellate cells to induce process elongationAlteration in cell shape (a) and gene expression (b) by ECM in cultured HSCs. Fig. 1a shows HSC shape after culturing on polystyrene surface (A), on type I collagen gel (B), in type I collagen gel (C), or on Matrigel (D). Fig. 1b indicates a representative PCR-DD showing differentially expressed transcripts in HSCs cultured on polystyrene (1), on type I collagen gel (2), or in type I collagen gel (3). Black and open arrowheads indicate the PCR products derived from down- and up-regulated transcripts, respectively, by extracellular type I collagen.Back to article page