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Table 3 GSH/GSSG levels in hepatocytes after in vivo treatment with Pb(NO3)2, GdCl3 or with 24 hours pretreatment of GdCl3 before exposure to Pb(NO3)2.*

From: Kupffer cells promote lead nitrate-induced hepatocyte apoptosis via oxidative stress

Days

Untreated

PbNO3

GdCl3

GdCl3/PbNO3

 

16.05/0.20 {3}

   

1

 

13.34/2.93 {3}

14.90/6.29 {2}

8.15/2.35 {2}

3

 

3.20/2.13 {10}

5.86/5.39 {10}

11.23/2.83 {6}

5

 

3.49/1.36 {39}

5.90/3.43 {15}

10.24/6.11 {18}

15

 

2.74/0.64 {20}

10.18/0.61 {10}

10.18/6.61 {10}

  1. * The values are given as total glutathione intracellular GSH/GSSG nmol/mg protein. The relative apoptotic percentages are reported in square brackets. Standard deviations did not exceed 5%. For each point 4 animals have been used.
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Comparative Hepatology

ISSN: 1476-5926