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Table 1 Time-course of necrosis, apoptosis and DNA synthesis in hepatocytes isolated from control, Pb(NO3)2-treated, and co-administered GdCl3 plus Pb(NO3)2 rats.*

From: Kupffer cells promote lead nitrate-induced hepatocyte apoptosis via oxidative stress

  Control Pb(NO3)2 GdCl3 + Pb(NO3)2 (2 hours) GdCl3 + Pb(NO3)2 (4 hours) GdCl3 + Pb(NO3)2 (24 hours)
%   1 day 3 days 5 days 1 day 3 days 5 days 1 day 3 days 5 days 1 day 3 days 5 days
Necrosis 5 (1.2) 7 (2.1) 8 (2.1) 5 (1.6) 15^(2.7) 16^(4.2) 20 (3.5) 13^(2.1) 15^(2.9) 21^(4.1) 15^(4.3) 12^(3.8) 10^(1.8)
Apoptosis 1 (0.2) 1 (0.2) 17^(5.3) 45^(8.0) 2 (0.9) 15^(2.3) 40 (4.1) 3 (0.5) 14^(3.5) 33^(6.1) 2 (0.9) 8^(2.6) 20^(3.4)
DNA** 4 (1.0) 3 (0.7) 10^(3.4) 9 (3.1) 5 (1.3) 12^(3.2) 6 (2.2) 6 (0.9) 12^(3.6) 7 (3.1) 1 (0.2) 8 (2.1) 5 (0.9)
  1. * Values are the mean (standard deviation) of at least three independent experiments of flow cytometry analysis. For each value at least 10 000 events were counted. ^Significantly different in relation to Control (p < 0.05). ** % of cells synthesizing DNA