Table 1 Time-course of necrosis, apoptosis and DNA synthesis in hepatocytes isolated from control, Pb(NO3)2-treated, and co-administered GdCl3 plus Pb(NO3)2 rats.*
From: Kupffer cells promote lead nitrate-induced hepatocyte apoptosis via oxidative stress
Control | Pb(NO3)2 | GdCl3 + Pb(NO3)2 (2 hours) | GdCl3 + Pb(NO3)2 (4 hours) | GdCl3 + Pb(NO3)2 (24 hours) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
% | 1 day | 3 days | 5 days | 1 day | 3 days | 5 days | 1 day | 3 days | 5 days | 1 day | 3 days | 5 days | |
Necrosis | 5 (1.2) | 7 (2.1) | 8 (2.1) | 5 (1.6) | 15^(2.7) | 16^(4.2) | 20 (3.5) | 13^(2.1) | 15^(2.9) | 21^(4.1) | 15^(4.3) | 12^(3.8) | 10^(1.8) |
Apoptosis | 1 (0.2) | 1 (0.2) | 17^(5.3) | 45^(8.0) | 2 (0.9) | 15^(2.3) | 40 (4.1) | 3 (0.5) | 14^(3.5) | 33^(6.1) | 2 (0.9) | 8^(2.6) | 20^(3.4) |
DNA** | 4 (1.0) | 3 (0.7) | 10^(3.4) | 9 (3.1) | 5 (1.3) | 12^(3.2) | 6 (2.2) | 6 (0.9) | 12^(3.6) | 7 (3.1) | 1 (0.2) | 8 (2.1) | 5 (0.9) |