(a, b, c, d), Patient 2, nodule a: type 3 lesion (same nodule as in Fig 2, but another region). This hyperplastic focus is surrounded with atrophic hepatocytes (a, b, d); arteries are seen at the periphery and inside the focus. A mild ductular reaction along the axis of arterioles is visualized by anti-CK7 immunostaining (c). A few isolated biliary cells (large arrow) and intermediate hepatocytic cells (small arrow) immunostain. Note the presence (a, b, d) of large venules near small arteries. Most sinusoids are capillarized, as shown by expression of CD34 by sinusoidal endothelial cells (d). a, H&E; b, anti-α-SMA; c, anti-CK7; d, anti-CD34 immunostaining.