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Table 3 Panel marker tests measuring fibrosis in ALD

From: Systematic review of the diagnostic performance of serum markers of liver fibrosis in alcoholic liver disease

Fibrosis grade Study No. Test AUROCS Cut off Sens Spec PPV NPV LR+ -LR
(95% CI) (95% CI)
Cirrhosis Poynard [16] 1991 624 PGA n/r 6 85 85 70 93 5.6 (4.5 7.01) 0.18 (0.12,0.25)
Cirrhosis Tran [19] 2000 146 Tran n/r   76 99 98 86 66.8 (9.5,471.2) 0.24 (0.15,0.37)
Cirrhosis Naveau [25] 2005 221 Fibrotest 0.95 (0.94, 0.96) 0.3 84 41 39 85 1.4 (1.2,1.7) 0.39 (0.2,0.70)
0.7 60 72 49 80 2.1 (1.6,2.9) 0.55 (0.40,0.75)
Cirrhosis Lieber [27] 2006 1034 APRI 0.79 >2.0 17 86 56 50 1.2 (0.9,1.6) 1.0 (0.92,1.02)
Cirrhosis Nguyen –Khac [28] 2008 103 Fibrotest 0.84 (0.72,0.97) n/r n/r n/r n/r n/r n/r n/r
Fibrometer 0.85 (0.74,0.96) n/r n/r n/r n/r n/r n/r n/r
Hepascore 0.76 (0.63,0.90) n/r n/r n/r n/r n/r n/r n/r
APRI 0.56 (0.38,0.73) n/r n/r n/r n/r n/r n/r n/r
PGA 0.89 (0.82 0.97) n/r n/r n/r n/r n/r n/r n/r
PGAA 0.83 (0.73-0.93) n/r n/r n/r n/r n/r n/r n/r
Cirrhosis Naveau [30] 2009 218 Fibrotest 0.94 (0.90,0.96) 0.56 90 n/r n/r n/r n/r n/r
0.78 n/r 90 n/r n/r n/r n/r
>0.30 100 50 47 100 2.0 0.50
>0.70 87 86 73 94 6.2 0.16
Fibrometer 0.94 (0.90,0.97) 0.92 90 n/r n/r n/r n/r n/r
0.997 n/r 90 n/r n/r n/r n/r
>0.50 99 62 54 99 2.6 0.38
>1.0 88 88 76 94 7.3 0.14
Hepascore 0.92 (0.87,0.97) 0.97 90 n/r n/r n/r n/r n/r
0.99 n/r 90 n/r n/r n/r n/r
Forns 0.38 (0.27,0.47) n/r n/r n/r n/r n/r n/r n/r
APRI 0.67 (0.59,0.75) n/r n/r n/r n/r n/r n/r n/r
FIB4 0.80 (0.72,0.86) n/r n/r n/r n/r n/r n/r n/r
F012vs 34 Severe Rosenberg [24] 2004 64 ELF 0.94 (0.84, 1.00) 0.087 100 17 75 100 1.2 (1.1, 1.4) 0.06 (0.01, 0.3)
0.431 93 100 100 86 68 (37,124) 0.08 (0.05,0.1)
F012vs 34 Severe Nguyen –Khac [28] 2008 103 FT 0.80 (0.7,0.9) n/r n/r n/r n/r n/r n/r n/r
Fibrometer 0.88 (0.8,0.95) n/r n/r n/r n/r n/r n/r n/r
Hepascore 0.83 (0.74,0.93) n/r n/r n/r n/r n/r n/r n/r
APRI 0.43 (0.30,0.56) n/r n/r n/r n/r n/r n/r n/r
PGA 0.84 (0.74 0.94) n/r n/r n/r n/r n/r n/r n/r
F012vs 34 Severe Lieber [29] 2008 247 HA n/r n/r 76 68 53 86 2.4 0.35
P3NP
TIMP1
Age
As panel
F01 vs 2-4 Mod/severe Cales [26] 2005 95 Fibrometer 0.96 (0.94, 0.98) n/r 92 93 99 76 18 (2.7,125) 0.08 (0.2)
F01vs 2-4 Mod-severe Naveau [22] 2005 221 Fibrotest 0.84 (0.81 0.87) 0.3 84 66 81 70 2.5 (1.8,3.4) 0.25 (0.16,0.40)
0.7 55 93 93 54 7.4 (3.3,16.1) 0.5 (0.4,0.6)
F01vs2-4 Mod severe Lieber [27] 2006 507 APRI 0.70 0.2 94 26 71 68 1.3 (1.2,1.4) 0.24 (0.17,0.33)
0.6 47 82 84 44 2.6 (2.0,3.3) 0.65 (0.6,0.71)
1.0 21 90 80 37 2.1 (1.5, 3.0) 0.88 (0.83,0.92)
1.6 13 95 83 36 2.5 (1.5,4.1) 0.92 (0.88,0.95)
2.0 9 97 86 35 3.1 (1.6,6.1) 0.94 (0.91,0.96)
F01vs2-4 Mod severe Nguyen –Khac [28] 2008 103 Fibrotest 0.79 (0.69,0.90)   n/r n/r n/r n/r n/r n/r
Fibrometer 0.82 (0.72,0.93)   n/r n/r n/r n/r n/r n/r
Hepascore 0.76 (0.64,0.88)   n/r n/r n/r n/r n/r n/r
APRI 0.54 (0.4-0.68)   n/r n/r n/r n/r n/r n/r
PGA 0.78 (0.68,0.89)   n/r n/r n/r n/r n/r n/r
PGAA 0.81 (0.71,0.91)   n/r n/r n/r n/r n/r n/r
F01vs2-4 Mod severe Naveau [30] 2009 218 Fibrotest 0.83 (0.77,0.88) 0.23 90 n/r n/r n/r n/r n/r
0.64 n/r 90 n/r n/r n/r n/r
>0.30 88 52 76 72 1.8 0.55
>0.70 43 97 96 50 14.3 0.07
Fibrometer 0.83 (0.77,0.87) 0.11 90 n/r n/r n/r n/r n/r
0.95 n/r 90 n/r n/r n/r n/r
>0.50 74 74 83 62 2.85 0.35
1.0 55 95 95 55 11.0 0.09
Hepascore 0.83 (0.77,0.88) 0.25 90 n/r n/r n/r n/r n/r
0.94 n/r 90 n/r n/r n/r n/r
Forns 0.38 (0.30,0.46) n/r n/r n/r n/r n/r n/r n/r
APRI 0.59 (0.51,0.67) n/r n/r n/r n/r n/r n/r n/r
FIB4 0.70 (0.62,0.76) n/r n/r n/r n/r n/r n/r n/r
Mild fibrosis Lieber [29] 2008 247 HA n/r n/r 74 76 86 53 3.1 0.34
P3NP
TIMP1
Age
As panel test
Any fibrosis Nguyen –Khac [28] 2008 103 Fibrotest 0.77 (0.63,0.90) n/r n/r n/r n/r n/r n/r n/r
Fibrometer 0.72 (0.57,0.87)
Hepascore 0.70 (0.51,0.89)
APRI 0.76 (0.58,0.95)
PGA 0.66 (0.50,0.82)
PGAA 0.74 (0.60,0.88)