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Table 3 Panel marker tests measuring fibrosis in ALD

From: Systematic review of the diagnostic performance of serum markers of liver fibrosis in alcoholic liver disease

Fibrosis grade

Study

No.

Test

AUROCS

Cut off

Sens

Spec

PPV

NPV

LR+

-LR

(95% CI)

(95% CI)

Cirrhosis

Poynard [16] 1991

624

PGA

n/r

6

85

85

70

93

5.6 (4.5 7.01)

0.18 (0.12,0.25)

Cirrhosis

Tran [19] 2000

146

Tran

n/r

 

76

99

98

86

66.8 (9.5,471.2)

0.24 (0.15,0.37)

Cirrhosis

Naveau [25] 2005

221

Fibrotest

0.95 (0.94, 0.96)

0.3

84

41

39

85

1.4 (1.2,1.7)

0.39 (0.2,0.70)

0.7

60

72

49

80

2.1 (1.6,2.9)

0.55 (0.40,0.75)

Cirrhosis

Lieber [27] 2006

1034

APRI

0.79

>2.0

17

86

56

50

1.2 (0.9,1.6)

1.0 (0.92,1.02)

Cirrhosis

Nguyen –Khac [28] 2008

103

Fibrotest

0.84 (0.72,0.97)

n/r

n/r

n/r

n/r

n/r

n/r

n/r

Fibrometer

0.85 (0.74,0.96)

n/r

n/r

n/r

n/r

n/r

n/r

n/r

Hepascore

0.76 (0.63,0.90)

n/r

n/r

n/r

n/r

n/r

n/r

n/r

APRI

0.56 (0.38,0.73)

n/r

n/r

n/r

n/r

n/r

n/r

n/r

PGA

0.89 (0.82 0.97)

n/r

n/r

n/r

n/r

n/r

n/r

n/r

PGAA

0.83 (0.73-0.93)

n/r

n/r

n/r

n/r

n/r

n/r

n/r

Cirrhosis

Naveau [30] 2009

218

Fibrotest

0.94 (0.90,0.96)

0.56

90

n/r

n/r

n/r

n/r

n/r

0.78

n/r

90

n/r

n/r

n/r

n/r

>0.30

100

50

47

100

2.0

0.50

>0.70

87

86

73

94

6.2

0.16

Fibrometer

0.94 (0.90,0.97)

0.92

90

n/r

n/r

n/r

n/r

n/r

0.997

n/r

90

n/r

n/r

n/r

n/r

>0.50

99

62

54

99

2.6

0.38

>1.0

88

88

76

94

7.3

0.14

Hepascore

0.92 (0.87,0.97)

0.97

90

n/r

n/r

n/r

n/r

n/r

0.99

n/r

90

n/r

n/r

n/r

n/r

Forns

0.38 (0.27,0.47)

n/r

n/r

n/r

n/r

n/r

n/r

n/r

APRI

0.67 (0.59,0.75)

n/r

n/r

n/r

n/r

n/r

n/r

n/r

FIB4

0.80 (0.72,0.86)

n/r

n/r

n/r

n/r

n/r

n/r

n/r

F012vs 34 Severe

Rosenberg [24] 2004

64

ELF

0.94 (0.84, 1.00)

0.087

100

17

75

100

1.2 (1.1, 1.4)

0.06 (0.01, 0.3)

0.431

93

100

100

86

68 (37,124)

0.08 (0.05,0.1)

F012vs 34 Severe

Nguyen –Khac [28] 2008

103

FT

0.80 (0.7,0.9)

n/r

n/r

n/r

n/r

n/r

n/r

n/r

Fibrometer

0.88 (0.8,0.95)

n/r

n/r

n/r

n/r

n/r

n/r

n/r

Hepascore

0.83 (0.74,0.93)

n/r

n/r

n/r

n/r

n/r

n/r

n/r

APRI

0.43 (0.30,0.56)

n/r

n/r

n/r

n/r

n/r

n/r

n/r

PGA

0.84 (0.74 0.94)

n/r

n/r

n/r

n/r

n/r

n/r

n/r

F012vs 34 Severe

Lieber [29] 2008

247

HA

n/r

n/r

76

68

53

86

2.4

0.35

P3NP

TIMP1

Age

As panel

F01 vs 2-4 Mod/severe

Cales [26] 2005

95

Fibrometer

0.96 (0.94, 0.98)

n/r

92

93

99

76

18 (2.7,125)

0.08 (0.2)

F01vs 2-4 Mod-severe

Naveau [22] 2005

221

Fibrotest

0.84 (0.81 0.87)

0.3

84

66

81

70

2.5 (1.8,3.4)

0.25 (0.16,0.40)

0.7

55

93

93

54

7.4 (3.3,16.1)

0.5 (0.4,0.6)

F01vs2-4 Mod severe

Lieber [27] 2006

507

APRI

0.70

0.2

94

26

71

68

1.3 (1.2,1.4)

0.24 (0.17,0.33)

0.6

47

82

84

44

2.6 (2.0,3.3)

0.65 (0.6,0.71)

1.0

21

90

80

37

2.1 (1.5, 3.0)

0.88 (0.83,0.92)

1.6

13

95

83

36

2.5 (1.5,4.1)

0.92 (0.88,0.95)

2.0

9

97

86

35

3.1 (1.6,6.1)

0.94 (0.91,0.96)

F01vs2-4 Mod severe

Nguyen –Khac [28] 2008

103

Fibrotest

0.79 (0.69,0.90)

 

n/r

n/r

n/r

n/r

n/r

n/r

Fibrometer

0.82 (0.72,0.93)

 

n/r

n/r

n/r

n/r

n/r

n/r

Hepascore

0.76 (0.64,0.88)

 

n/r

n/r

n/r

n/r

n/r

n/r

APRI

0.54 (0.4-0.68)

 

n/r

n/r

n/r

n/r

n/r

n/r

PGA

0.78 (0.68,0.89)

 

n/r

n/r

n/r

n/r

n/r

n/r

PGAA

0.81 (0.71,0.91)

 

n/r

n/r

n/r

n/r

n/r

n/r

F01vs2-4 Mod severe

Naveau [30] 2009

218

Fibrotest

0.83 (0.77,0.88)

0.23

90

n/r

n/r

n/r

n/r

n/r

0.64

n/r

90

n/r

n/r

n/r

n/r

>0.30

88

52

76

72

1.8

0.55

>0.70

43

97

96

50

14.3

0.07

Fibrometer

0.83 (0.77,0.87)

0.11

90

n/r

n/r

n/r

n/r

n/r

0.95

n/r

90

n/r

n/r

n/r

n/r

>0.50

74

74

83

62

2.85

0.35

1.0

55

95

95

55

11.0

0.09

Hepascore

0.83 (0.77,0.88)

0.25

90

n/r

n/r

n/r

n/r

n/r

0.94

n/r

90

n/r

n/r

n/r

n/r

Forns

0.38 (0.30,0.46)

n/r

n/r

n/r

n/r

n/r

n/r

n/r

APRI

0.59 (0.51,0.67)

n/r

n/r

n/r

n/r

n/r

n/r

n/r

FIB4

0.70 (0.62,0.76)

n/r

n/r

n/r

n/r

n/r

n/r

n/r

Mild fibrosis

Lieber [29] 2008

247

HA

n/r

n/r

74

76

86

53

3.1

0.34

P3NP

TIMP1

Age

As panel test

Any fibrosis

Nguyen –Khac [28] 2008

103

Fibrotest

0.77 (0.63,0.90)

n/r

n/r

n/r

n/r

n/r

n/r

n/r

Fibrometer

0.72 (0.57,0.87)

Hepascore

0.70 (0.51,0.89)

APRI

0.76 (0.58,0.95)

PGA

0.66 (0.50,0.82)

PGAA

0.74 (0.60,0.88)

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Comparative Hepatology

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