NAC potentiates the effect of IFN by decreasing cell viability of HCC HepG2 cell line. Treatment with IFN or NAC, at 2.5x104 U/mL and 10 mM, respectively, significantly reduced cell viability after 48, 72, and 96 h of treatment. Treatment with NAC+IFN in the same doses significantly reduced cell viability after 24, 48, 72, and 96 h of treatment. Values are shown as means and standard errors of the mean (SEM). a-IFN x CO p<0.05. b- NAC x CO p<0.01. c- NAC+IFN x IFN p<0.05.