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Table 3 Changes in apoptotic and pre apoptotic genes expression in HCV infected HepG2 cell line in vitro.

From: Characterization of chronic HCV infection-induced apoptosis

  Qualitative/Quantitative PCR (copy number/ml)   Apoptotic gene
Days Cell free media Cell lysate Bcl-xL Bcl-2 Bak Fas FasL
Day1 Positive/785 Positive - + +++ ++ -
Day2 Positive/Negative Positive - + + ++ -
Day3 Negative/Negative Positive - + ++ ++ -
Day7 Positive/13005 Positive - + + - -
Day14 Positive/Negative Positive - + + - -
Day21 Negative/6782 Positive - + - - +
Day28 Negative/24678 Positive + + ++ - +
Day35 Positive/8892 Negative - + - - +
Day45 Positive/Negative Positive + + - - ++
Day52 Positive/7374 Negative - + - - +++
Day59 Positive/22963 Positive + + ++ - +++
HepG2 Control - - - + + + -
  1. +: Equal to the expression level in the HepG2; ++: twofold increase in the expression level; +++ threefold increase in the expression level.