Quantification of the hepatocytes' cross-sectional area of rats exposed to a restricted feeding schedule for 3 weeks (food intake from 12:00 to 14:00 h). Data are derived from evaluation of the hepatocyte morphology (Figure 2). RFS group, black box; ad-libitum-fed control group, white box; 24-h-fasting control group, hatched and gray box. Results are expressed as mean ± SEM of 6 independent determinations. Significant difference between food restricted and ad-libitum fed groups [*], within the same experimental group [+], and different from 24-h fasting group [×]. Differences derived from Tukey's post hoc test (α = 0.05).