Examples of canine hepatocellular tumours with high K19 expression. Immunohistochemical staining of K19 positive cells is shown in (A). HE staining, trabeculae of hepatocytes with cell pleomorphism and multiple mitotic figures (arrowheads) are shown in (B). Immunohistochemical staining of glypican-3 positive cells is shown in (C). Immunohistochemical staining for HepPar-1 with tumour negative area and positive area of surrounding non-neoplastic liver (arrow) is shown in (D).