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Table 1 Folds and mRNA changes in HepG2 cells infected with C. trachomatis at different infectivity rates.

From: Chlamydia trachomatisgrowth inhibition and restoration of LDL-receptor level in HepG2 cells treated with mevastatin

Parameter

Non-infected cells

Infected cells

  

MOI 1

MOI2

36B4ct

18.37

18.26

18.01

HMG-CoA Red

1

1.31

0.98

HMG-CoA Synth

1

1.06

0.87

SS

1

1.21

0.89

LDL-R

1

0.76

0.56

LRP

1

0.87

0.99

FAS

1

0.88

0.89

  1. HepG2 cells were set up, grown and infected with C. trachomatis in presence or absence of mevastatin as described in Methods. RNA was extracted in 48 hours after inoculation of the bacteria. RNA levels for the genes of interest were normalized to 36B4 expression level, whose CT values are represented in the upper row of the Table. All RNA values in the infected cells are referenced to non-infected control