Figure 3

Macro-and microscopic changes after three weeks of shunting. a) Close-up photograph of the transition zone between shunted and portally perfused in-vivo liver after three weeks. The shunted side exhibits smaller condensed lobuli and a brighter (hyperoxygenized) color, while the portally perfused side exhibits larger lobuli, b) HE stained section of the transition zone showing more condensed lobuli on the shunted side and larger lobuli with dilated portal venules and central veins on the portally perfused side, c) sections from areas perfused by the portal vein and by the shunt showing an even distribution of Ki67 positive cells (control sections of sham and baseline livers all show a lower density of Ki67 positive cells).