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Table 4 ROC curve values for sTNFR-II and IL-8 in PNALT and HCC patients

From: Serum levels of soluble Fas, soluble tumor necrosis factor-receptor II, interleukin-2 receptor and interleukin-8 as early predictors of hepatocellular carcinoma in Egyptian patients with hepatitis C virus genotype-4

ROC values sTNF-RII ≥ 398 IL-8 ≥ 345 TNFR-II ≥ 398 or IL-8 <290
Sensitivity 73.3% 96.7% 100%
Specificity 88.2% 76.5% 70.6%
AUC 0.849 0.588 0.794
NPV 65.2% 92.2% 100%
PPV 91.7% 87.9% 85.7%
  1. ROC - receiving operating characteristic; AUC - area under the curve; NPV - negative predictive value; PPV - positive predictive value; PNALT: Chronic hepatitis C with persistent normal alanine aminotrasferase. HCC: hepatocellular carcinoma.