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Table 2 Serum levels of sFas, sTNFR-II, sIL-2R and IL-8 in the different study groups.

From: Serum levels of soluble Fas, soluble tumor necrosis factor-receptor II, interleukin-2 receptor and interleukin-8 as early predictors of hepatocellular carcinoma in Egyptian patients with hepatitis C virus genotype-4

Cytokines

(pg/ml)

Control

PNALT

CLD

HCC

p-value

sFas

316 ± 62.5b

605.82 ± 304ab

814.94 ± 362a

762.18 ± 437a

< 0.001

sTNF-RII

375.26 ± 58.4ab

268.58 ± 129b

315.27 ± 133.5b

480.16 ± 154.4a

< 0.001

sIL-2Rα

639.84 ± 78.7b

710.10 ± 422b

845.38 ± 385.2ab

1372.58 ± 779.6a

0.001

IL-8

345.84 ± 75.6a

350.7 ± 53.6a

352.33 ± 98.3a

228.61 ± 51.1b

< 0.001

  1. Values are expressed as mean ± SD. Groups with similar letters are not statistically different. A p-value < 0.05 was considered significant; PNALT: chronic hepatitis C with persistent normal alanine aminotrasferase; CLD: chronic liver disease; HCC: hepatocellular carcinoma.