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Table 1 IC50% values for competing radiolabelled dexamethasone from specific binding to rat liver microsomes.

From: Low affinity glucocorticoid binding site ligands as potential anti-fibrogenics

Cold Competitor

IC50% (10-6 M)

dexamethasone

0.098 ± 0.003

progesterone

0.081 ± 0.010

clotrimazole

40 ± 12

metyrapone

310 ± 52

haloperidol

> 10000

  1. Data are the mean and standard deviation of at least 3 separate microsomal (isolated from different animals) determinations.
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Comparative Hepatology

ISSN: 1476-5926