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Table 1 Mutated viral strain analysis. Percentages of viral strain carrying the rtM204V/I or the rtN236T mutation determined with in-house selective real-time PCR (ARMS).

From: Sustained virological and biochemical responses to lamivudine and adefovir dipivoxil combination in a chronic hepatitis B infection despite mutations conferring resistance to both drugs

Date Treatment HBV viral load (log IU/mL) % rtM204 (wt) % rtM204V % rtM204I % rtN236 (wt) % rtN236T
M0 LMV 8.6 100 0 0 - -
M3 LMV 5.2 100 0 0 - -
M7 LMV 6.1 28 48 24 - -
M10 LMV 8.1 34 45 21 - -
M12 LMV 8.6 22 58 20 - -
M14 LMV 8.8 30 50 20 - -
M16 LMV + ADV 5.9 8 67 25 - -
M19 LMV + ADV 5.2 37 43 20 - -
M22 LMV + ADV 4.8 24 51 25 - -
M24 LMV + ADV 4.6 26 49 25 - -
M27 LMV + ADV 4.1 66 19 15 - -
M30 LMV + ADV 4.2 66 22 12 - -
M36 ADV 3.3 83 7 10 100 0
M39 ADV 3.3 74 8 18 100 0
M42 ADV 2.6 75 8 17 96 4
M46 ADV 3.4 82 8 10 79 21
M48 ADV 4.1 98 2 0 66 34
M51 LMV + ADV 3.0 87 0 13 71 29
M55 LMV + ADV 2.9 86 14 0 73 27
  1. Note: wt = wild type, -: not done