Table 1 Mutated viral strain analysis. Percentages of viral strain carrying the rtM204V/I or the rtN236T mutation determined with in-house selective real-time PCR (ARMS).
Date | Treatment | HBV viral load (log IU/mL) | % rtM204 (wt) | % rtM204V | % rtM204I | % rtN236 (wt) | % rtN236T |
|---|---|---|---|---|---|---|---|
M0 | LMV | 8.6 | 100 | 0 | 0 | - | - |
M3 | LMV | 5.2 | 100 | 0 | 0 | - | - |
M7 | LMV | 6.1 | 28 | 48 | 24 | - | - |
M10 | LMV | 8.1 | 34 | 45 | 21 | - | - |
M12 | LMV | 8.6 | 22 | 58 | 20 | - | - |
M14 | LMV | 8.8 | 30 | 50 | 20 | - | - |
M16 | LMV + ADV | 5.9 | 8 | 67 | 25 | - | - |
M19 | LMV + ADV | 5.2 | 37 | 43 | 20 | - | - |
M22 | LMV + ADV | 4.8 | 24 | 51 | 25 | - | - |
M24 | LMV + ADV | 4.6 | 26 | 49 | 25 | - | - |
M27 | LMV + ADV | 4.1 | 66 | 19 | 15 | - | - |
M30 | LMV + ADV | 4.2 | 66 | 22 | 12 | - | - |
M36 | ADV | 3.3 | 83 | 7 | 10 | 100 | 0 |
M39 | ADV | 3.3 | 74 | 8 | 18 | 100 | 0 |
M42 | ADV | 2.6 | 75 | 8 | 17 | 96 | 4 |
M46 | ADV | 3.4 | 82 | 8 | 10 | 79 | 21 |
M48 | ADV | 4.1 | 98 | 2 | 0 | 66 | 34 |
M51 | LMV + ADV | 3.0 | 87 | 0 | 13 | 71 | 29 |
M55 | LMV + ADV | 2.9 | 86 | 14 | 0 | 73 | 27 |