TY - JOUR AU - Wickert, Lucia AU - Chatain, Nicolas AU - Kruschinsky, Karin AU - Gressner, Axel M. PY - 2007 DA - 2007/05/02 TI - Glucocorticoids activate TGF-β induced PAI-1 and CTGF expression in rat hepatocytes JO - Comparative Hepatology SP - 5 VL - 6 IS - 1 AB - In addition to the activation of hepatic stellate cells TGF-β govern apoptosis and growth control of hepatocytes in liver injury. In non-parenchymal cells, TGF-β induces plasminogen activator inhibitor 1 (PAI-1) and connective tissue growth factor (CTGF) expression, which are involved in extra cellular matrix formation. Both genes were also regulated by glucocorticoids, which in certain cases showed antagonistic effects to the TGF-β-Smad 3 pathway. The purpose of our work was to investigate the influence of TGF-β and dexamethasone on PAI-1 and CTGF expression and secretion in primary hepatocytes. SN - 1476-5926 UR - https://doi.org/10.1186/1476-5926-6-5 DO - 10.1186/1476-5926-6-5 ID - Wickert2007 ER -