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Table 1 Expression of ET-1; ETA and ETB receptors in the liver of wild-type and ecNOS knock-out mice.

From: Sensitivity to endothelin-1 is decreased in isolated livers of endothelial constitutive nitric oxide synthase knockout mice

 

Wild-type

ecNOS knock-out

mRNA for ET-1

14.8 ± 0.5

15.0 ± 0.2

mRNA for ETA†

9.9 ± 0.3

11.4 ± 0.3*

mRNA for ETB

11.5 ± 0.7

11.9 ± 0.3

  1. All results are expressed as mean ± standard deviation (n = 6 animals per group). The two animal groups were compared by Student's t-test. † the 1.5 cycle increase in ETA mRNA in ecNOS knock-out mice indicates a 65% decrease in mRNA compared to wild-type mice. * p = 0.0005.
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Comparative Hepatology

ISSN: 1476-5926