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Table 1 Expression of ET-1; ETA and ETB receptors in the liver of wild-type and ecNOS knock-out mice.

From: Sensitivity to endothelin-1 is decreased in isolated livers of endothelial constitutive nitric oxide synthase knockout mice

  Wild-type ecNOS knock-out
mRNA for ET-1 14.8 ± 0.5 15.0 ± 0.2
mRNA for ETA 9.9 ± 0.3 11.4 ± 0.3*
mRNA for ETB 11.5 ± 0.7 11.9 ± 0.3
  1. All results are expressed as mean ± standard deviation (n = 6 animals per group). The two animal groups were compared by Student's t-test. † the 1.5 cycle increase in ETA mRNA in ecNOS knock-out mice indicates a 65% decrease in mRNA compared to wild-type mice. * p = 0.0005.