Endothelin-1 enhances fibrogenic gene expression, but does not promote DNA synthesis or apoptosis in hepatic stellate cells

Table 1 The effects of endothelin-1 on apoptosis induced serum deprivation in 1st and 4th passage HSC.

	1^st passage HSC			4^th passage HSC
	Apoptosis after serum deprivation			Apoptosis after serum deprivation
	72 hr (%)	120 hr (%)	168 hr (%)	72 hr (%)	120 hr (%)	168 hr (%)
Control	38.8 ± 7.5	40.2 ± 6.6	55.6 ± 10.0	40.2 ± 3.2	46.9 ± 5.2	42.3 ± 5.6
ET-1(10^-8 M)	37.3 ± 9.3	42.4 ± 4.6	56.3 ± 8.0	35.3 ± 4.4	46.9 ± 3.4	36.7 ± 3.3
ET-1(10^-6 M)	31.9 ± 9.9	40.1 ± 5.5	53.3 ± 11.3	36.7 ± 5.8	55.4 ± 14.3	46.2 ± 11.9