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Table 1 The effects of endothelin-1 on apoptosis induced serum deprivation in 1st and 4th passage HSC.

From: Endothelin-1 enhances fibrogenic gene expression, but does not promote DNA synthesis or apoptosis in hepatic stellate cells

  1st passage HSC 4th passage HSC
  Apoptosis after serum deprivation Apoptosis after serum deprivation
  72 hr (%) 120 hr (%) 168 hr (%) 72 hr (%) 120 hr (%) 168 hr (%)
Control 38.8 ± 7.5 40.2 ± 6.6 55.6 ± 10.0 40.2 ± 3.2 46.9 ± 5.2 42.3 ± 5.6
ET-1(10-8 M) 37.3 ± 9.3 42.4 ± 4.6 56.3 ± 8.0 35.3 ± 4.4 46.9 ± 3.4 36.7 ± 3.3
ET-1(10-6 M) 31.9 ± 9.9 40.1 ± 5.5 53.3 ± 11.3 36.7 ± 5.8 55.4 ± 14.3 46.2 ± 11.9
  1. Data are given as mean ± standard deviation. ET-1: endothelin-1.