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Figure 5 | Comparative Hepatology

Figure 5

From: Endothelin-1 enhances fibrogenic gene expression, but does not promote DNA synthesis or apoptosis in hepatic stellate cells

Figure 5

Effect of ET receptor antagonists on procollagen α1(I) mRNA expression of 1st passage HSC. Cells were stimulated with 10-6 M ET-1 in the absence or presence of the ETAR antagonist BQ123 (10-6 M) or the ETBR antagonist BQ788 (10-6 M) for 48 hours. The mRNA levels were determined by real time quantitative PCR. Results are given as mean ± SD (n = 4). **p < 0.01 vs control, ## p < 0.01 vs ET-1 (10-6 M).

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