Synthesis of acute phase proteins in rats with cirrhosis exposed to lipopolysaccharide

Comparative Hepatology

Table 1 Animal and model characteristics

	Bilirubin μmol/l **	ASAT U/l *	Liver weight (gram) *	Spleen weight (gram)*
Sham	2.7 (0.5)	332 (143)	9.1 (0.8)	0.64 (0.10)
Sham+LPS	3.2 (0.89	345 (156)	8.8 (0.8)	0.76 (0.12)
Cirrhosis	39.5 (3.8)	519 (210)	18.5 (2.8)	1.37 (0.42)
Cirrhosis+LPS	54.2 (7.8)	912 (406)	16.5 (2.4)	1.27 (0.20)

Values are given as: mean (SD). Bilirubin and ASAT (n = 9) and liver/spleen-weights (n = 10) in sham-operated, in sham-operated injected with LPS (bilirubin and ASAT: n = 10, liver/spleen-weights: n = 12), in cirrhotic (bilirubin and ASAT: n = 11, liver/spleen-weights: n = 12) and in cirrhotic animals injected with LPS (n = 9). **Significantly increased (2-way ANOVA, P < 0.001) by both factors i.e. LPS and cirrhosis. *Significantly increased only by cirrhosis (2-way ANOVA, P < 0.001).