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Table 2 Plasma levels of vitellogenin and sex steroid hormones in juvenile Atlantic cod exposed in vivo to ketoconazole and xenoestrogens.

From: Interactions between xenoestrogens and ketoconazole on hepatic CYP1A and CYP3A, in juvenile Atlantic cod (Gadus morhua)

Treatment Vitellogenin 17β-Estradiol Testosterone 11-Keto-Testosterone
  (μg/ml plasma) (pg/ml plasma) (pg/ml plasma) (pg/ml plasma)
  n = 7–8 n = 8 n = 7–8 n = 6–8
Vehicle (5 ml peanut oil/kg b.w.) 0.6 (1.0) 62 (56) 86 (68) 33 (38)
Ketoconazole (KC) (12 mg/kg b.w.) 0.6 (0.9) 60 (26) 120 (78) 71 (46)
Nonylphenol (NP) (25 mg/kg b.w.) 266 (199) a 76 (52) 75 (33) 42 (67)
Ethynylestradiol (5 mg/kg b.w.) 4,350 (1,463) a 100 (69) 90 (40) 35 (23)
KC + NP (12 + 25 mg/kg b.w.) 268 (205) a 36 (28) 61 (51) 36 (38)
  1. a Significantly different from vehicle treated fish (P < 0.001; Kruskal-Wallis ANOVA, followed by Mann-Whitney U-test). Each value represents the mean from 6–8 fish, followed by the SD, in brackets.