Table 2 Plasma levels of vitellogenin and sex steroid hormones in juvenile Atlantic cod exposed in vivo to ketoconazole and xenoestrogens.
Treatment | Vitellogenin | 17β-Estradiol | Testosterone | 11-Keto-Testosterone |
|---|---|---|---|---|
(μg/ml plasma) | (pg/ml plasma) | (pg/ml plasma) | (pg/ml plasma) | |
n = 7–8 | n = 8 | n = 7–8 | n = 6–8 | |
Vehicle (5 ml peanut oil/kg b.w.) | 0.6 (1.0) | 62 (56) | 86 (68) | 33 (38) |
Ketoconazole (KC) (12 mg/kg b.w.) | 0.6 (0.9) | 60 (26) | 120 (78) | 71 (46) |
Nonylphenol (NP) (25 mg/kg b.w.) | 266 (199) a | 76 (52) | 75 (33) | 42 (67) |
Ethynylestradiol (5 mg/kg b.w.) | 4,350 (1,463) a | 100 (69) | 90 (40) | 35 (23) |
KC + NP (12 + 25 mg/kg b.w.) | 268 (205) a | 36 (28) | 61 (51) | 36 (38) |