The diagnostic value of biomarkers (SteatoTest) for the prediction of liver steatosis

Poynard, Thierry; Ratziu, Vlad; Naveau, Sylvie; Thabut, Dominique; Charlotte, Frederic; Messous, Djamila; Capron, Dominique; Abella, Annie; Massard, Julien; Ngo, Yen; Munteanu, Mona; Mercadier, Anne; Manns, Michael; Albrecht, Janice

doi:10.1186/1476-5926-4-10

Comparative Hepatology

Table 4 Diagnostic value of SteatoTest for predicting liver steatosis greater than 5%.

From: The diagnostic value of biomarkers (SteatoTest) for the prediction of liver steatosis

Cut-off	Sensitivity	Specificity	Positive Predictive Value	Negative Predictive Value
Training Group N = 310			Prevalence = 45%
SteatoTest 0.30	0.91 (127/140)	0.45 (77/170)	0.58 (127/220)	0.86 (77/90)
SteatoTest 0.50	0.69 (97/140)	0.74 (126/170)	0.69 (97/141)	0.75 (126/169)
SteatoTest 0.70	0.45 (63/140)	0.89 (152/170)	0.78 (63/81)	0.66 (152/229)
GGT 50 IU/L	0.66 (92/140)	0.55 (94/170)	0.55 (92/168)	0.66 (94/142)
ALT 50 IU/L	0.77 (108/140)	0.35 (60/170)	0.50 (108/218)	0.65 (60/92)
Validation Group1 N = 171			Prevalence = 26%
SteatoTest 0.30	0.98 (44/45)	0.24 (30/126)	0.31 (44/140)	0.97 (30/31)
SteatoTest 0.50	0.89 (40/45)	0.58 (73/126)	0.43 (40/93)	0.94 (73/78)
SteatoTest 0.70	0.44 (20/45)	0.83 (105/126)	0.49 (20/41)	0.81 (105/130)
GGT 50 IU/L	0.62 (28/45)	0.61 (72/126)	0.34 (28/82)	0.81 (72/89)
ALT 50 IU/L	1.00 (45/45)	0.06 (8/126)	0.28 (45/163)	1.00 (8/8)
Validation Group 2 N = 201			Prevalence = 11%
SteatoTest 0.30	1.00 (22/22)	0.56 (100/179)	0.22 (22/101)	1.00 (100/100)
SteatoTest 0.50	0.68 (15/22)	0.79 (142/179)	0.29 (15/52)	0.95 (142/149)
SteatoTest 0.70	0.32 (7/22)	0.92 (165/179)	0.33 (7/21)	0.92 (165/180)
GGT 50 IU/L	0.09 (2/22)	0.97 (174/179)	0.29 (2/7)	0.90 (174/194)
ALT 50 IU/L	0.05 (1/22)	0.98 (176/179)	0.25 (1/3)	0.89 (176/197)
Validation Group 3 N = 62			Prevalence = 94%
SteatoTest 0.30	0.85 (49/58)	0.00 (0/4)	0.93 (49/53)	0.00 (0/9)
SteatoTest 0.50	0.62 (36/58)	1.00 (4/4)	1.00 (36/36)	0.15 (4/26)
SteatoTest 0.70	0.40 (23/58)	1.00 (4/4)	1.00 (23/23)	0.10 (4/39)
GGT 50 IU/L	0.90 (52/58)	0.00 (0/4)	0.93 (52/56)	0.00 (0/6)
ALT 50 IU/L	0.53 (31/58)	0.75 (3/4)	0.97 (31/32)	0.10 (3/30)
All Groups N = 884			Prevalence = 30%
SteatoTest 0.30	0.90 (238/265)	0.54 (336/619)	0.46 (238/521)	0.93 (336/363)
SteatoTest 0.50	0.72 (190/265)	0.75 (466/619)	0.55 (190/343)	0.86 (466/541)
SteatoTest 0.70	0.46 (122/265)	0.88 (546/619)	0.63 (122/195)	0.79 (546/689)
GGT 50 IU/L	0.66 (174/265)	0.76 (468/619)	0.54 (174/325)	0.84 (468/559)
ALT 50 IU/L	0.72 (185/265)	0.62 (382/619)	0.44 (185/422)	0.83 (382/462)

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