Overview of the diagnostic value of biochemical markers of liver fibrosis (FibroTest, HCV FibroSure) and necrosis (ActiTest) in patients with chronic hepatitis C

Table 6 Summary of the diagnostic value of ActiTest for the differential diagnosis of all grades of necroinflammatory hepatic activity, according to the AUROCs.

	A0	A1	A2	A3	BD A0	A0A1	A1A2	A2A3
Blood Donor BD n = 300	0.67	0.84	0.96	0.99	-	0.79	0.89	0.97
A0 n = 185	-
A1 n = 443	0.69	-
A2 n = 370	0.87	0.70	-
A3 n = 272	*0.93*	0.79	0.60	-
A0A1	-	-	0.70	0.83	-
A1A2	0.77	-	-	0.70	0.85	-
A2A3	0.89	0.74	-	-	0.94	0.78	-
A0A1A2	-	-	-	0.75	-	-	-	-
BD A0A1	-	-	0.82	0.88	-	-	-	0.84

The AUROCs between all different grade combinations are given. Between two contiguous grades (one-grade difference), the AUROCs are given in bold. Between patients with a two-grades difference, the AUROCs are given in italics. Between patients with a three-grades difference, the AUROCs are given in bold and italics. Between patients with a four- or five-grades difference (blood donors versus F3 or F4, and F0 versus F4), the AUROCs are underlined. Significant differences were observed between AUROCs when there was a two-grade or more difference.