Overview of the diagnostic value of biochemical markers of liver fibrosis (FibroTest, HCV FibroSure) and necrosis (ActiTest) in patients with chronic hepatitis C

Table 5 Summary of the diagnostic value of FibroTest for the diagnosis of all stage combinations of hepatic fibrosis, according to the AUROCs.

	F0	F1	F2	F3	F4	BD F0	F0F1	F1F2	F2F3F4	F3F4
Blood Donor (BD) n = 300	0.71	0.86	*0.95*	0.99	0.99	-	0.84	0.88	0.97	0.99
F0 n = 95	-
F1 n = 688	0.66	-
F2 n = 253	0.82	0.69	-
F3 n = 111	*0.92*	0.80	0.63	-
F4 n = 123	0.95	*0.87*	0.75	0.65	-
BD F0	0.71	0.81	0.92	0.98	0.98	-
F0F1	-	-	0.71	0.82	0.88	-	-	-
F1F2	0.71	-	0.69	0.81	0.82	0.84	-	-	-
F2F3	0.85	0.76	-	-	0.72	0.92	0.80	-	-
F3F4	0.94	0.81	0.81	-	-	0.98	0.89	0.80	-
F2F3F4	0.83	0.78	-	-	-	0.95	0.78	-	-	-
BD F0F1	-	-	0.77	0.87	0.91	-	-	-	0.83	0.89

The AUROC between all different stage combinations are given. Between two contiguous stages (one- stage difference), the AUROCs are given in bold. Between patients with a two-stages difference, the AUROCs are given in italics. Between patients with a three-stages difference, the AUROCs are given in bold and italics. Between patients with a four- or five-stages difference (blood donors versus F3 or F4, and F0 versus F4), the AUROCs are underlined. Significant differences were observed between AUROCs when there was a two-stage or more difference.