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Table 4 Integrated database, with predictive values for the diagnosis of significant necroinflammatory hepatic activity according to METAVIR conversion cut offs. Derived from published studies.

From: Overview of the diagnostic value of biochemical markers of liver fibrosis (FibroTest, HCV FibroSure) and necrosis (ActiTest) in patients with chronic hepatitis C

Integrated database Patient number Marker Grade/Prevalence AUROC (SE) Cut off used for METAVIR stages conversion Sensitivity Specificity Negative predictive value Positive predictive value
With Blood Donors 1,570 ActiTest A2A3/0.41 0.85 (0.01) 0.17 0.95 0.55 0.94 0.60
      0.29 0.87 0.69 0.88 0.66
      0.36 0.81 0.74 0.85 0.69
      0.52 0.62 0.86 0.76 0.75
      0.60 0.51 0.90 0.72 0.77
      0.61 0.50 0.90 0.72 0.78
      0.62 0.49 0.91 0.72 0.78
Without blood donors 1,270 ActiTest A2A3/0.51 0.78 (0.01) 0.17 0.95 0.40 0.89 0.62
      0.29 0.87 0.55 0.80 0.67
      0.36 0.81 0.63 0.76 0.69
      0.52 0.62 0.79 0.67 0.75
      0.60 0.51 0.85 0.63 0.77
      0.61 0.50 0.85 0.62 0.78
      0.62 0.49 0.86 0.62 0.78