Overview of the diagnostic value of biochemical markers of liver fibrosis (FibroTest, HCV FibroSure) and necrosis (ActiTest) in patients with chronic hepatitis C

Table 4 Integrated database, with predictive values for the diagnosis of significant necroinflammatory hepatic activity according to METAVIR conversion cut offs. Derived from published studies.

Integrated database	Patient number	Marker	Grade/Prevalence	AUROC (SE)	Cut off used for METAVIR stages conversion	Sensitivity	Specificity	Negative predictive value	Positive predictive value
With Blood Donors	1,570	ActiTest	A2A3/0.41	0.85 (0.01)	0.17	0.95	0.55	0.94	0.60
					0.29	0.87	0.69	0.88	0.66
					0.36	0.81	0.74	0.85	0.69
					0.52	0.62	0.86	0.76	0.75
					0.60	0.51	0.90	0.72	0.77
					0.61	0.50	0.90	0.72	0.78
					0.62	0.49	0.91	0.72	0.78
Without blood donors	1,270	ActiTest	A2A3/0.51	0.78 (0.01)	0.17	0.95	0.40	0.89	0.62
					0.29	0.87	0.55	0.80	0.67
					0.36	0.81	0.63	0.76	0.69
					0.52	0.62	0.79	0.67	0.75
					0.60	0.51	0.85	0.63	0.77
					0.61	0.50	0.85	0.62	0.78
					0.62	0.49	0.86	0.62	0.78