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Table 1 Summary of the diagnostic value of FibroTest for the staging of hepatic fibrosis and comparisons with hyaluronic acid, the Forns Index and the APRI Index in patients with chronic hepatitis C, from the published studies.

From: Overview of the diagnostic value of biochemical markers of liver fibrosis (FibroTest, HCV FibroSure) and necrosis (ActiTest) in patients with chronic hepatitis C

First author N* Methodology Marker Stage/Prevalence AUROC SE Cut off Sensitivity Specificity
Imbert-Bismut, 2001 189 Prospective
Single center
First year cohort
FibroTest F2F3F4 / 0.38 0.84 (0.03) 0.10
0.30
0.60
0.80
0.97
0.79
0.51
0.29
0.24
0.65
0.94
0.95
Imbert-Bismut, 2001 134 Prospective
Single center
Validation cohort
FibroTest F2F3F4 / 0.45 0.87 (0.03) 0.10
0.30
0.60
0.80
1.00
0.87
0.70
0.38
0.22
0.59
0.95
0.97
Poynard, 2001 165 Retrospective
Randomized trial
Multicenter
FibroTest F3F4 Knodell / 0.32 0.74 (0.03) 0.10
0.30
0.60
0.80
0.96
0.81
0.50
0.13
0.24
0.65
0.92
0.98
Poynard, 2001 165 Retrospective
Randomized trial
Multicenter
Hyaluronic F3F4 Knodell / 0.32 0.65 (0.03) 20
40
100
0.81
0.47
0.23
0.39
0.65
0.91
Poynard, 2003 352 Retrospective
Randomized trial
Multicenter
Before treatment
FibroTest F2F3F4 / 0.39 0.73 (0.03) 0.10
0.30
0.60
0.80
0.97
0.86
0.50
0.20
0.08
0.45
0.79
0.95
Poynard, 2003 352 Retrospective
Randomized trial
Multicenter
After treatment
FibroTest F2F3F4 / 0.32 0.77 (0.03) 0.10
0.30
0.60
0.80
0.98
0.85
0.46
0.16
0.15
0.39
0.81
0.97
Rossi, 2003 125 Prospective
Multicenter
Non-validated analyzers
FibroTest F2F3F4 / 0.38 0.74 (0.05) 0.10
0.30
0.60
0.80
0.92
0.75
0.42
0.22
0.29
0.61
0.94
0.96
Myers, 2003 130 Retrospective
Single center
HCV-HIV Co-infection
FibroTest F2F3F4 / 0.45 0.86 (0.04) 0.10
0.30
0.60
0.80
0.98
0.90
0.66
0.34
0.17
0.60
0.92
0.96
Thabut, 2003 249 Retrospective
Single center
From Imbert-Bismut, 2001
FibroTest F2F3F4 / 0.38 0.84 (0.02) 0.10
0.30
0.60
0.80
0.98
0.84
0.58
0.29
0.22
0.65
0.93
0.95
Thabut, 2003 249 Retrospective
Single center
From Imbert-Bismut, 2001
Forns Index F2F3F4 / 0.38 0.78 (0.03) 1
3
6
8
1.00
1.00
0.55
0.19
0.04
0.26
0.86
0.97
Le Calvez, 2004 323 Retrospective
Single center
From Imbert-Bismut, 2001
FibroTest F2F3F4 / 0.41 0.83 (0.02) 0.10
0.30
0.60
0.80
0.97
0.81
0.58
0.33
0.30
0.66
0.93
0.95
Le Calvez, 2004 323 Retrospective
Single center
From Imbert-Bismut, 2001
APRI Index F2F3F4 / 0.41 0.74 (0.03) 0.50
1.00
1.50
2.00
0.81
0.54
0.36
0.24
0.56
0.84
0.91
0.95
Callewaert, 2004 82 Prospective FibroTest F4 / 0.29 0.89 (0.04) 0.10
0.30
0.60
0.80
1.00
0.92
0.79
0.67
0.33
0.62
0.81
0.92
Callewaert, 2004 82 Prospective Glyco Cirrho Test F4 ** / 0.29 0.87 (0.04) -0.2
0.1
0.4
0.6
1.00
0.79
0.21
0.17
0.12
0.88
0.95
1.00
  1. * Number of patients. ** Compensated