Distribution of keratin IFs and K8 pS79 in hepatocytes from control and GF-fed C3H mice. A, C, E, G keratin IFs; B, D, F, H K8 pS79; A, B) control; C, D) 2 week treatment; E, F) 6 week treatment; G, H) 5 month treatment. Arrow in D indicates clusters of cells containing K8 pS79; asterisk shows a damaged hepatocyte. Filled arrowheads in G and H indicate MBs reactive with Troma 1 and LJ4 (anti-K8 pS79), respectively; empty arrowheads indicate MBs reactive with Troma 1 but not with LJ4 (anti-K8 pS79), respectively. Scale bar = 20 μm.