Distribution of keratin IFs and K18 pS33 in hepatocytes from control and GF-fed C3H mice. A, C, E, G keratin IFs; B, D, F, H K18 pS33; A, B) control; C, D) 2 week treatment; E, F) 6 week treatment; G, H) 5 month treatment. Asterisk in D shows an hepatocyte containing a high level of K18 pS33; arrow indicates a dilated bile canaliculi. Filled arrowheads in G and H indicate reactive MBs with Troma 1 and Ab8250 (anti-K18 pS33), respectively. Scale bar = 20 μm.