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Table 1 Characteristics of included apparently healthy volunteers and patients

From: Intra-individual fasting versuspostprandial variation of biochemical markers of liver fibrosis (FibroTest) and activity (ActiTest)

 

Apparently healthy volunteers

Patients

Number of patients

29

35

Characteristics

  

Age (years) [mean (SD)]***

36 (8)

52 (15)

Male [n (%)]

12 (41)

22 (63)

Female [n (%)]

17 (59)

13 (37)

Ethnic Origin

  

   Caucasian [n (%)]

19 (65)

20 (60)

   Non Caucasian [n (%)]

10 (35)

15 (40)

   Black/Asian/Other (n)

5/1/4

5/3/7

Weight (kg) [mean (SD)]

68.2 (10.8)

69.7 (14.8)

Height [mean (SD)]

170 (9.5)

169 (7.6)

Body Mass Index (kg/m2) [mean (SD)]

23.6 (3.4)

24.4 (5.1)

Alcohol in g per day [n (%)]

  

   0

21 (72)

21 (64)

   0–50

8 (28)

8 (24)

   Over 50

0 (0)

4 (12)

Drug [n (%)]

8 (28)

29 (83)

   Anti-diabetic (n)

0

7

   Oral contraception (n)

2

7

   Other (n)

6

15

Associated Disease

0

35

Alcoholic Liver Disease (%)

0

10 (29)

Hepatitis C (%)

0

6 (17)

Hepatitis B (%)

0

4 (11)

Human Immunodeficiency Virus Infection (%)

0

1 (3)

Other (%)

0

14 (40)

Histological prediction fasting

  

Necrotico-inflammatory activity

  

   No or minimal activity (%)

28

14

   Moderate or severe activity (%)

1

21

Fibrosis

  

   No or minimal fibrosis (%)

28

14

   Moderate (%)

1

5

   Extensive fibrosis or cirrhosis (%)

0

16

Baseline Biochemistry fasting

  

   ALT (IU/L) [mean (SD)]***

23.7 (16.3)

67.4 (53.8)

   Total Bilirubin (μmoles/L) [mean (SD)]

13.9 (7.6)

27.1 (31.7)

   GGT U/L (7–32 female) (11–49 male) [mean (SD)]***

21 (15.9)

147 (149)

   Alpha2 macroglobulin g/L (1.6–4.0) [mean (SD)]

1.77 (0.43)

2.15 (0.78)

   ApoA1 g/L (1.2–1.7) [mean (SD)]*

1.56 (0.24)

1.26 (0.55)

   Haptoglobin g/l (0.35–2.00) [mean (SD)]

1.06 (0.35)

0.86 (0.66)

   Conjugated bilirubin (μmoles/L) [mean (SD)]*

3.25 (1.5)

28.9 (22.5)

   Gilbert possible (%)

7

0

   Fibrosis Index (range 0.00–1.00) [mean (SD)]***

0.13 (0.08)

0.55 (0.33)

   Activity Index (range 0.00–1.00) [mean (SD)]***

0.09 (0.1)

0.42 (0.24)

   AST (IU/L) [mean (SD)]***

26 (10)

60 (34)

   Triglycerides (umol/L) [mean (SD)]

1.0 (0.76)

1.7 (2.6)

   Cholesterol (umol/L) [mean (SD)]

4.8 (1.2)

4.5 (1.8)

   Blood glucose (umol/L) [mean (SD)]**

4.2 (0.56)

5.9 (3.12)

Dietary factors

  

   Total calories (kcal)

788

774

   Lipids (%)

38

35

   Carbohydrates (%)

45

44

   Proteins (%)

15

18

   Fibers (g)

6

8

  1. *Significant difference between groups P < 0.05; **Significant difference between groups P < 0.001; ***Significant difference between groups P < 0.0001.