Apparently healthy volunteers | Patients | |
---|---|---|
Number of patients | 29 | 35 |
Characteristics | ||
Age (years) [mean (SD)]*** | 36 (8) | 52 (15) |
Male [n (%)] | 12 (41) | 22 (63) |
Female [n (%)] | 17 (59) | 13 (37) |
Ethnic Origin | ||
Caucasian [n (%)] | 19 (65) | 20 (60) |
Non Caucasian [n (%)] | 10 (35) | 15 (40) |
Black/Asian/Other (n) | 5/1/4 | 5/3/7 |
Weight (kg) [mean (SD)] | 68.2 (10.8) | 69.7 (14.8) |
Height [mean (SD)] | 170 (9.5) | 169 (7.6) |
Body Mass Index (kg/m2) [mean (SD)] | 23.6 (3.4) | 24.4 (5.1) |
Alcohol in g per day [n (%)] | ||
0 | 21 (72) | 21 (64) |
0–50 | 8 (28) | 8 (24) |
Over 50 | 0 (0) | 4 (12) |
Drug [n (%)] | 8 (28) | 29 (83) |
Anti-diabetic (n) | 0 | 7 |
Oral contraception (n) | 2 | 7 |
Other (n) | 6 | 15 |
Associated Disease | 0 | 35 |
Alcoholic Liver Disease (%) | 0 | 10 (29) |
Hepatitis C (%) | 0 | 6 (17) |
Hepatitis B (%) | 0 | 4 (11) |
Human Immunodeficiency Virus Infection (%) | 0 | 1 (3) |
Other (%) | 0 | 14 (40) |
Histological prediction fasting | ||
Necrotico-inflammatory activity | ||
No or minimal activity (%) | 28 | 14 |
Moderate or severe activity (%) | 1 | 21 |
Fibrosis | ||
No or minimal fibrosis (%) | 28 | 14 |
Moderate (%) | 1 | 5 |
Extensive fibrosis or cirrhosis (%) | 0 | 16 |
Baseline Biochemistry fasting | ||
ALT (IU/L) [mean (SD)]*** | 23.7 (16.3) | 67.4 (53.8) |
Total Bilirubin (μmoles/L) [mean (SD)] | 13.9 (7.6) | 27.1 (31.7) |
GGT U/L (7–32 female) (11–49 male) [mean (SD)]*** | 21 (15.9) | 147 (149) |
Alpha2 macroglobulin g/L (1.6–4.0) [mean (SD)] | 1.77 (0.43) | 2.15 (0.78) |
ApoA1 g/L (1.2–1.7) [mean (SD)]* | 1.56 (0.24) | 1.26 (0.55) |
Haptoglobin g/l (0.35–2.00) [mean (SD)] | 1.06 (0.35) | 0.86 (0.66) |
Conjugated bilirubin (μmoles/L) [mean (SD)]* | 3.25 (1.5) | 28.9 (22.5) |
Gilbert possible (%) | 7 | 0 |
Fibrosis Index (range 0.00–1.00) [mean (SD)]*** | 0.13 (0.08) | 0.55 (0.33) |
Activity Index (range 0.00–1.00) [mean (SD)]*** | 0.09 (0.1) | 0.42 (0.24) |
AST (IU/L) [mean (SD)]*** | 26 (10) | 60 (34) |
Triglycerides (umol/L) [mean (SD)] | 1.0 (0.76) | 1.7 (2.6) |
Cholesterol (umol/L) [mean (SD)] | 4.8 (1.2) | 4.5 (1.8) |
Blood glucose (umol/L) [mean (SD)]** | 4.2 (0.56) | 5.9 (3.12) |
Dietary factors | ||
Total calories (kcal) | 788 | 774 |
Lipids (%) | 38 | 35 |
Carbohydrates (%) | 45 | 44 |
Proteins (%) | 15 | 18 |
Fibers (g) | 6 | 8 |