|
Number of patients
|
29
|
35
|
|
Characteristics
| | |
|
Age (years) [mean (SD)]***
|
36 (8)
|
52 (15)
|
|
Male [n (%)]
|
12 (41)
|
22 (63)
|
|
Female [n (%)]
|
17 (59)
|
13 (37)
|
|
Ethnic Origin
| | |
|
Caucasian [n (%)]
|
19 (65)
|
20 (60)
|
|
Non Caucasian [n (%)]
|
10 (35)
|
15 (40)
|
|
Black/Asian/Other (n)
|
5/1/4
|
5/3/7
|
|
Weight (kg) [mean (SD)]
|
68.2 (10.8)
|
69.7 (14.8)
|
|
Height [mean (SD)]
|
170 (9.5)
|
169 (7.6)
|
|
Body Mass Index (kg/m2) [mean (SD)]
|
23.6 (3.4)
|
24.4 (5.1)
|
|
Alcohol in g per day [n (%)]
| | |
|
0
|
21 (72)
|
21 (64)
|
|
0–50
|
8 (28)
|
8 (24)
|
|
Over 50
|
0 (0)
|
4 (12)
|
|
Drug [n (%)]
|
8 (28)
|
29 (83)
|
|
Anti-diabetic (n)
|
0
|
7
|
|
Oral contraception (n)
|
2
|
7
|
|
Other (n)
|
6
|
15
|
|
Associated Disease
|
0
|
35
|
|
Alcoholic Liver Disease (%)
|
0
|
10 (29)
|
|
Hepatitis C (%)
|
0
|
6 (17)
|
|
Hepatitis B (%)
|
0
|
4 (11)
|
|
Human Immunodeficiency Virus Infection (%)
|
0
|
1 (3)
|
|
Other (%)
|
0
|
14 (40)
|
|
Histological prediction fasting
| | |
|
Necrotico-inflammatory activity
| | |
|
No or minimal activity (%)
|
28
|
14
|
|
Moderate or severe activity (%)
|
1
|
21
|
|
Fibrosis
| | |
|
No or minimal fibrosis (%)
|
28
|
14
|
|
Moderate (%)
|
1
|
5
|
|
Extensive fibrosis or cirrhosis (%)
|
0
|
16
|
|
Baseline Biochemistry fasting
| | |
|
ALT (IU/L) [mean (SD)]***
|
23.7 (16.3)
|
67.4 (53.8)
|
|
Total Bilirubin (μmoles/L) [mean (SD)]
|
13.9 (7.6)
|
27.1 (31.7)
|
|
GGT U/L (7–32 female) (11–49 male) [mean (SD)]***
|
21 (15.9)
|
147 (149)
|
|
Alpha2 macroglobulin g/L (1.6–4.0) [mean (SD)]
|
1.77 (0.43)
|
2.15 (0.78)
|
|
ApoA1 g/L (1.2–1.7) [mean (SD)]*
|
1.56 (0.24)
|
1.26 (0.55)
|
|
Haptoglobin g/l (0.35–2.00) [mean (SD)]
|
1.06 (0.35)
|
0.86 (0.66)
|
|
Conjugated bilirubin (μmoles/L) [mean (SD)]*
|
3.25 (1.5)
|
28.9 (22.5)
|
|
Gilbert possible (%)
|
7
|
0
|
|
Fibrosis Index (range 0.00–1.00) [mean (SD)]***
|
0.13 (0.08)
|
0.55 (0.33)
|
|
Activity Index (range 0.00–1.00) [mean (SD)]***
|
0.09 (0.1)
|
0.42 (0.24)
|
|
AST (IU/L) [mean (SD)]***
|
26 (10)
|
60 (34)
|
|
Triglycerides (umol/L) [mean (SD)]
|
1.0 (0.76)
|
1.7 (2.6)
|
|
Cholesterol (umol/L) [mean (SD)]
|
4.8 (1.2)
|
4.5 (1.8)
|
|
Blood glucose (umol/L) [mean (SD)]**
|
4.2 (0.56)
|
5.9 (3.12)
|
|
Dietary factors
| | |
|
Total calories (kcal)
|
788
|
774
|
|
Lipids (%)
|
38
|
35
|
|
Carbohydrates (%)
|
45
|
44
|
|
Proteins (%)
|
15
|
18
|
|
Fibers (g)
|
6
|
8
|
