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Table 1 Characteristics of included apparently healthy volunteers and patients

From: Intra-individual fasting versuspostprandial variation of biochemical markers of liver fibrosis (FibroTest) and activity (ActiTest)

  Apparently healthy volunteers Patients
Number of patients 29 35
Characteristics   
Age (years) [mean (SD)]*** 36 (8) 52 (15)
Male [n (%)] 12 (41) 22 (63)
Female [n (%)] 17 (59) 13 (37)
Ethnic Origin   
   Caucasian [n (%)] 19 (65) 20 (60)
   Non Caucasian [n (%)] 10 (35) 15 (40)
   Black/Asian/Other (n) 5/1/4 5/3/7
Weight (kg) [mean (SD)] 68.2 (10.8) 69.7 (14.8)
Height [mean (SD)] 170 (9.5) 169 (7.6)
Body Mass Index (kg/m2) [mean (SD)] 23.6 (3.4) 24.4 (5.1)
Alcohol in g per day [n (%)]   
   0 21 (72) 21 (64)
   0–50 8 (28) 8 (24)
   Over 50 0 (0) 4 (12)
Drug [n (%)] 8 (28) 29 (83)
   Anti-diabetic (n) 0 7
   Oral contraception (n) 2 7
   Other (n) 6 15
Associated Disease 0 35
Alcoholic Liver Disease (%) 0 10 (29)
Hepatitis C (%) 0 6 (17)
Hepatitis B (%) 0 4 (11)
Human Immunodeficiency Virus Infection (%) 0 1 (3)
Other (%) 0 14 (40)
Histological prediction fasting   
Necrotico-inflammatory activity   
   No or minimal activity (%) 28 14
   Moderate or severe activity (%) 1 21
Fibrosis   
   No or minimal fibrosis (%) 28 14
   Moderate (%) 1 5
   Extensive fibrosis or cirrhosis (%) 0 16
Baseline Biochemistry fasting   
   ALT (IU/L) [mean (SD)]*** 23.7 (16.3) 67.4 (53.8)
   Total Bilirubin (μmoles/L) [mean (SD)] 13.9 (7.6) 27.1 (31.7)
   GGT U/L (7–32 female) (11–49 male) [mean (SD)]*** 21 (15.9) 147 (149)
   Alpha2 macroglobulin g/L (1.6–4.0) [mean (SD)] 1.77 (0.43) 2.15 (0.78)
   ApoA1 g/L (1.2–1.7) [mean (SD)]* 1.56 (0.24) 1.26 (0.55)
   Haptoglobin g/l (0.35–2.00) [mean (SD)] 1.06 (0.35) 0.86 (0.66)
   Conjugated bilirubin (μmoles/L) [mean (SD)]* 3.25 (1.5) 28.9 (22.5)
   Gilbert possible (%) 7 0
   Fibrosis Index (range 0.00–1.00) [mean (SD)]*** 0.13 (0.08) 0.55 (0.33)
   Activity Index (range 0.00–1.00) [mean (SD)]*** 0.09 (0.1) 0.42 (0.24)
   AST (IU/L) [mean (SD)]*** 26 (10) 60 (34)
   Triglycerides (umol/L) [mean (SD)] 1.0 (0.76) 1.7 (2.6)
   Cholesterol (umol/L) [mean (SD)] 4.8 (1.2) 4.5 (1.8)
   Blood glucose (umol/L) [mean (SD)]** 4.2 (0.56) 5.9 (3.12)
Dietary factors   
   Total calories (kcal) 788 774
   Lipids (%) 38 35
   Carbohydrates (%) 45 44
   Proteins (%) 15 18
   Fibers (g) 6 8
  1. *Significant difference between groups P < 0.05; **Significant difference between groups P < 0.001; ***Significant difference between groups P < 0.0001.