Figure 4From: Peroxynitrite formation and sinusoidal endothelial cell injury during acetaminophen-induced hepatotoxicity in miceLiver sections were stained with H&E 6 h after administration of 300 mg/kg acetaminophen (AAP). One group of animals was pretreated with 10 mg/kg gadolinium chloride (A), the other group was pretreated with 100 mg/kg allopurinol (B). AAP-GdCl 3 (A): Livers exhibited severe hemorrhage and centrilobular necrosis. AAP-Allopurinol (B): The liver was histologically normal.Back to article page