Figure 1

Effect of Kupffer cell inhibition on mediator secretion (TNF-alpha, PGE₂ and NOx) by PCLS, obtained from rats pretreated with GdCl₃ (Gd+) or NaCl (Gd-) 24 h before experiment; PCLS were incubated during 2 h and 20 h in the presence of LPS (from left to right, each group of three bars correspond to: 0 micrograms/ml, 0.1 micrograms/ml, 10 micrograms/ml). Values are means é S.E.M (n é 3; *p < 0.05 Gd+ vs Gd-, two-way ANOVA; ^a p < 0.05 LPS 10 micrograms/ml vs LPS 0 micrograms/ml and ^b p < 0.05 LPS 10 micrograms/ml vs LPS 0.1 micrograms/ml, two-way ANOVA followed by Tukey's post hoc test).