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Table 1 Hepatoprotection by Heme Oxygenase-1 Induction

From: Heme oxygenase-1 induction in hepatocytes and non-parenchymal cells protects against liver injury during endotoxemia

  Caspase 3 Activity (–F/min/mg protein) Plasma ALT Activity (U/L)
Controls 48 – 6 56 – 9
G/ET 479 – 23* 3700 – 900*
G/ET + 5 CoPP 289 – 28*,# 245 – 120*,#
G/ET + 15 CoPP 51 – 2# 51 – 14#
G/ET + SnPP 486 – 10* 2442 – 333*
G/ET + 5 CoPP/SnPP 573 – 94* 2486 – 679*
G/TNF 554 – 35* 1680 – 210*
G/TNF + 5 CoPP 671 – 97* 2420 – 600*
G/TNF + 15 CoPP 305 – 55*,# 126 – 39#
  1. Apoptosis (caspase-3) and oncosis (alanine aminotransferase, ALT) were measured 7 h after Gal/ET or Gal/TNF treatment. Animals were pretreated for 18 h with cobalt protoporphyrin (5 or 15 mg/kg CoPP) and 12 h with tin protoporphyrin (15 mg/kg SnPP). Data represent means – SE of n = 5 animals per group. *P < 0.05 (compared to controls) #P < 0.05 (compared to Gal/ET or Gal/TNF).