Heme oxygenase-1 induction in hepatocytes and non-parenchymal cells protects against liver injury during endotoxemia

Table 1 Hepatoprotection by Heme Oxygenase-1 Induction

	Caspase 3 Activity (–F/min/mg protein)	Plasma ALT Activity (U/L)
Controls	48 – 6	56 – 9
G/ET	479 – 23*	3700 – 900*
G/ET + 5 CoPP	289 – 28*,^#	245 – 120*^,#
G/ET + 15 CoPP	51 – 2^#	51 – 14^#
G/ET + SnPP	486 – 10*	2442 – 333*
G/ET + 5 CoPP/SnPP	573 – 94*	2486 – 679*
G/TNF	554 – 35*	1680 – 210*
G/TNF + 5 CoPP	671 – 97*	2420 – 600*
G/TNF + 15 CoPP	305 – 55*,^#	126 – 39^#

Apoptosis (caspase-3) and oncosis (alanine aminotransferase, ALT) were measured 7 h after Gal/ET or Gal/TNF treatment. Animals were pretreated for 18 h with cobalt protoporphyrin (5 or 15 mg/kg CoPP) and 12 h with tin protoporphyrin (15 mg/kg SnPP). Data represent means – SE of n = 5 animals per group. *P < 0.05 (compared to controls) ^#P < 0.05 (compared to Gal/ET or Gal/TNF).