Table 5 Effect of thalidomide on LPS-induced TNF-alpha mRNA expression and TNF-alpha production in cultured Kupffer cells.
From: Thalidomide Prevents Alcoholic Liver Injury in Rats Through Inhibition of Kupffer Cell Sensitization
(A) TNF-alpha and beta-actin mRNA expression | |
|---|---|
| Â | TNF-alpha/beta-actin(%1 h LPS) |
LPS (100 ng/ml) 1 hour | 100 |
LPS + Thalido (5 micromolar) 1 hour | 97 |
LPS 3 hours | 65 |
LPS + Thalido 3 hours | 41 |
(B) TNF-alpha production | |
| Â | TNF-alpha (pg/ml) |
LPS (100 ng/ml) | 501 – 19 |
LPS + Thalido (5 micromolar) | 268 – 4* |