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Table 4 Hepatic GSH levels after treatment with Pb(NO3)2, GdCl3 or with 24 hours pretreatment of GdCl3 before exposure to Pb(NO3)2 .*

From: Kupffer cells promote lead nitrate-induced hepatocyte apoptosis via oxidative stress

Weeks Untreated / BSO PbNO3 GdCl3 GdCl3 / PbNO3
   3 days 5 days 3 days 5 days 3 days 5 days
- 29.00       
1 17.76 {- 3%} 13.80 11.02 14.05 16.03 16.03 18.09
2 9.65 {- 47%} 8.50 5.70 8.90 11.02 6.20 10.10
3 5.09 {- 72%} 6.65 4.30 6.42 7.90 6.10 8.80
  1. * GSH values are given as nmol / mg protein. Animals were fed with 2 mM BSO for 1, 2 or 3 weeks before injection with the different heavy metals, and the GSH content was evaluated at 3 and 5 days after the injection. Standard deviations did not exceed 5%. In brackets is the percentage of decrement of GSH levels relative to control untreated animals. Each value is the mean of 3 independent experiments, using 3 different animals.