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Table 4 Hepatic GSH levels after treatment with Pb(NO3)2, GdCl3 or with 24 hours pretreatment of GdCl3 before exposure to Pb(NO3)2 .*

From: Kupffer cells promote lead nitrate-induced hepatocyte apoptosis via oxidative stress

Weeks

Untreated / BSO

PbNO3

GdCl3

GdCl3 / PbNO3

  

3 days

5 days

3 days

5 days

3 days

5 days

-

29.00

      

1

17.76 {- 3%}

13.80

11.02

14.05

16.03

16.03

18.09

2

9.65 {- 47%}

8.50

5.70

8.90

11.02

6.20

10.10

3

5.09 {- 72%}

6.65

4.30

6.42

7.90

6.10

8.80

  1. * GSH values are given as nmol / mg protein. Animals were fed with 2 mM BSO for 1, 2 or 3 weeks before injection with the different heavy metals, and the GSH content was evaluated at 3 and 5 days after the injection. Standard deviations did not exceed 5%. In brackets is the percentage of decrement of GSH levels relative to control untreated animals. Each value is the mean of 3 independent experiments, using 3 different animals.