Figure 2

Light micrographs of rat liver sections (a,c) from control animals and (b,d) three days after a single GdCl₃ injection; (a, b) toluidine blue staining and (c, d) unstained sections of livers of GdCl₃-treated rats. In normal livers large Kupffer cells, lining liver sinusoids are indicated by arrows(a) or evidenced by the colloidal carbon particles uptaken by Kupffer cells (c) (arrowheads); b) three days after GdCl₃ administration; the majority of large Kupffer cells disappeared from liver and (d) the phagocytic activity is depressed as the scarce internalization of carbon shows (arrowhead). The asterisk (b) indicates a hepatocyte in mitosis. Bar = 10 μm.