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Table 2 Diagnostic performance of single markers

From: Systematic review of the diagnostic performance of serum markers of liver fibrosis in alcoholic liver disease

Degree of fibrosis tested Study No. AUC Cut off used Sens Spec PPV NPV LR + (95% CI) LR – (95% CI)
HA
Cirrhosis Oberti [18] (1997) 109* n/r 60mcg/l 100 60 78 97 2.5 (1.7,3.6) 0.02(0.004,0.18)
Tran [19] (2000) 146 n/r 60mcg/l 100 86 83 99 6.8 (4.1,11.4) 0.02 (0.004,0.1)
Plevris [21] (2000) 70 n/r 100mcg/l 87 89 n/a n/a 8.0 0.15
Stickel [23] (2003) 87 0.78 250mcg/l 100 69 35 98 3 (2.0, 4.28) 0.10 (0.02,0.69)
Naveau [25] (2005) 221 0.93 (0.91,0.95) n/r n/r n/r n/r n/r n/r n/r
Nguyen-Khac [28] (2008) 103 0.80 (0.68,0.92_ n/r n/r n/r n/r n/r n/r n/r
Stage 012 vs34 Stickel [23] (2003) 87 0.76 55.5 mcg/l 83 69 67 83 3(1.7, 4.2) 0.26 (0.13,0.53)
Nguyen-Khac [28] (2008) 103 - 0.83 (0.74-0.92)        
Lieber [29] (2008) 247 0.69        
F01vs 234 Naveau [25] (2005) 221 0.79 (0.76-0.82) n/r n/r n/r n/r n/r n/r  
Nguyen-Khac [28] (2008) 103 0.80 (0.70-0.92) n/r n/r n/r n/r n/r n/r n/r
Degree of Fibrosis tested Study No. AUC (95%CI) Cut off used Sens Spec PPV NPV LR + (95% CI) LR-(95% CI)
F0 vs 1-4 Nguyen-Khac [28] (2008) 103 0.76 (0.58-0.94) n/r n/r n/r n/r n/r n/r n/r
P3NP
F012 vs34 Gabrielli [15] (1989) 44 n/r 16 ng/ml 71 50 n/r n/r 1.4 0.6
Lieber [29] (2008) 247 0.67        
F0 vs F1-6 Gabriella [15] (1989) 44 n/r 16 ng/ml 90 59 n/r n/r 2 0.2
Li [17] (1994) 44 0.80 ±0.07 1.1 U/ml 45 100 94 44 6.8 (0.99, 47) 0.6 (0.42, 0.82)
Prothrombin Index**
Cirrhosis Oberti [18] (1997) 109 n/r 85% n/r n/r n/r n/r n/r n/r
Croquet [22] (2002) 240 n/r 80% 81 99 99 85 101(14.3,713.5 0.2 (0.13,0.28)
Tran [19] (2000) 146 n/r 85% 83 93 89 89 12.1(5.56,26.5) 0.2 (0.1,0.33)
TIMP1
F012 vs 34(advanced fibrosis) Lieber [29] (2008) 247 0.68   n/r n/r n/r n/r n/r n/r
Any fibrosis (1994) Li [17] 44 0.96 ±0.03 313 ng/ml n/r n/r n/r n/r n/r n/r
YKL
Cirrhosis Tran [19] (2000) 146 n/r 330mcg/l 51 89 75 74 5 (2.4,8.6) 0.5 (0.4,0.7)
ApoA1
Cirrhosis Tran [19] (2000) 146 n/r 1.2 g/l 83 93 89 89 12.1 (5.6,26.5) 0.18 (0.10,0.33)