Table 2 Diagnostic performance of single markers

HA

Cirrhosis

Oberti [18] (1997)

109*

n/r

60mcg/l

100

60

78

97

2.5 (1.7,3.6)

0.02(0.004,0.18)

Tran [19] (2000)

146

n/r

60mcg/l

100

86

83

99

6.8 (4.1,11.4)

0.02 (0.004,0.1)

Plevris [21] (2000)

70

n/r

100mcg/l

87

89

n/a

n/a

8.0

0.15

Stickel [23] (2003)

87

0.78

250mcg/l

100

69

35

98

3 (2.0, 4.28)

0.10 (0.02,0.69)

Naveau [25] (2005)

221

0.93 (0.91,0.95)

n/r

n/r

n/r

n/r

n/r

n/r

n/r

Nguyen-Khac [28] (2008)

103

0.80 (0.68,0.92_

n/r

n/r

n/r

n/r

n/r

n/r

n/r

Stage 012 vs34

Stickel [23] (2003)

87

0.76

55.5 mcg/l

83

69

67

83

3(1.7, 4.2)

0.26 (0.13,0.53)

Nguyen-Khac [28] (2008)

103 -

0.83 (0.74-0.92)

Lieber [29] (2008)

247

0.69

F01vs 234

Naveau [25] (2005)

221

0.79 (0.76-0.82)

n/r

n/r

n/r

n/r

n/r

n/r

Nguyen-Khac [28] (2008)

103

0.80 (0.70-0.92)

n/r

n/r

n/r

n/r

n/r

n/r

n/r

Degree of Fibrosis tested

Study

No.

AUC (95%CI)

Cut off used

Sens

Spec

PPV

NPV

LR + (95% CI)

LR-(95% CI)

F0 vs 1-4

Nguyen-Khac [28] (2008)

103

0.76 (0.58-0.94)

n/r

n/r

n/r

n/r

n/r

n/r

n/r

P3NP

F012 vs34

Gabrielli [15] (1989)

44

n/r

16 ng/ml

71

50

n/r

n/r

1.4

0.6

Lieber [29] (2008)

247

0.67

F0 vs F1-6

Gabriella [15] (1989)

44

n/r

16 ng/ml

90

59

n/r

n/r

2

0.2

Li [17] (1994)

44

0.80 ±0.07

1.1 U/ml

45

100

94

44

6.8 (0.99, 47)

0.6 (0.42, 0.82)

Prothrombin Index**

Cirrhosis

Oberti [18] (1997)

109

n/r

85%

n/r

n/r

n/r

n/r

n/r

n/r

Croquet [22] (2002)

240

n/r

80%

81

99

99

85

101(14.3,713.5

0.2 (0.13,0.28)

Tran [19] (2000)

146

n/r

85%

83

93

89

89

12.1(5.56,26.5)

0.2 (0.1,0.33)

TIMP1

F012 vs 34(advanced fibrosis)

Lieber [29] (2008)

247

0.68

n/r

n/r

n/r

n/r

n/r

n/r

Any fibrosis (1994)

Li [17]

44

0.96 ±0.03

313 ng/ml

n/r

n/r

n/r

n/r

n/r

n/r

YKL

Cirrhosis

Tran [19] (2000)

146

n/r

330mcg/l

51

89

75

74

5 (2.4,8.6)

0.5 (0.4,0.7)

ApoA1

Cirrhosis

Tran [19] (2000)

146

n/r

1.2 g/l

83

93

89

89

12.1 (5.6,26.5)

0.18 (0.10,0.33)