Table 2 Genes proposed to regulate angiogenesis with specific functions according to Ace View[46]
From: The genetic regulation of the terminating phase of liver regeneration
Resection Group | Up-regulated | Down-regulated | Function |
|---|---|---|---|
3-0 weeks | FGF9 (0.3) | Involved in cell growth | |
VEGFA (−0,7) | Inducing angiogenesis, vasculogenesis and endothelial cell growth | ||
6-0 weeks | EDG1 (0,3) | Regulate differentiation of endothelial cells | |
VASH2 (−0,4) | Positive regulation of angiogenesis and endothelial cell proliferation | ||
6-3 weeks | ANGPTL2 (0,3) | Growth factor specific for vascular endothelium | |
FGF20 (0,4) | Involved in cell growth | ||
VASH2 (−0,3) | Positive regulation of angiogenesis and endothelial cell proliferation | ||
Sham Group | |||
3-0 weeks | ANGPTL3 (0,2) | Growth factor specific for vascular endothelium | |
ANGPT2 (−0,2) | Negative regulation of angiogenesis by inducing endothelial cell apoptosis | ||
6-0 weeks | FAP (0,2) | Involved in control of fibroblast growth | |
FGF9 (0,3) | Involved in cell growth | ||
FGFBP3 (0,3) | Positive regulation of fibroblast growth factor | ||
VEZF1 (0,8) | Participates in angiogenesis | ||
6-3 weeks | VEZF1 (1,0) | Involved in angiogenesis | |
VEZF1 (0,7) | Involved in angiogenesis | ||
AMOTL2 (−0,2) | Angiomotin binds angiostatin, an inhibitor of angiogenesis | ||
FGFR1OP (−0,2) | Involved in angiogenesis and cell growth | ||
Control Group | |||
3-0 weeks | AMOTL1 (0,4) | Angiomotin binds angiostatin, an inhibitor of angiogenesis | |
FGF8 (−0,6) | Involved in cell growth | ||
6-0 weeks | AMOTL1 (0,7) | Angiomotin binds angiostatin, an inhibitor of angiogenesis | |
FGF20 (0,4) | Involved in cell growth | ||
FGFR3 (−0,2) | Involved in cell growth | ||
6-3 weeks | FGF8 (0,4) | Overexpression has been shown to increase tumor growth and angiogenesis | |
VEZF1 (−0,9) | Involved in angiogenesis |