From: The genetic regulation of the terminating phase of liver regeneration
Resection Group | Up-regulated | Down-regulated | Function |
---|---|---|---|
3-0 weeks | PRKRA (0.8) | Negative regulator of cell proliferation | |
GSK3A (0.3) | Negative regulator of cell proliferation | ||
IGFBP7 (0.9) | Regulation of cell proliferation | ||
TIA1 (−1.8) | Inducer of apoptosis | ||
6-0 weeks | ZNF490 (2.0) | Negative effect on cell cycle progression and promotes apoptosis | |
CCT7 (0.4) | Is implicated in positive control of the G(1)/S phase transition | ||
BAG3 (−1.1) | Prevents FAS-mediated apoptosis | ||
TP53INP1 (−0.9) | Induces apoptosis | ||
TOB (−0.3) | Regulates cell growth | ||
6-3 weeks | ZNF490 (2.4) | Negative effect on cell cycle progression and promotes apoptosis | |
CARD11 (0.4) | Activates caspases that play a central role in apoptosis | ||
PTHLH (0.4) | Positive and negative regulator of cell proliferation | ||
FAF1 (−1.1) | Increases cell death | ||
Sham Group | |||
3-0 weeks | MDM4 (1.9) | Potentially inhibits the G1 phase of the cell cycle | |
E2F2 (0.3) | Helps regulate the expression of a number of genes that are important in cell proliferation | ||
WWOX (0.2) | Negatively regulates the progression through the cell cycle | ||
UMOD (0.9) | Negative regulator of cell proliferation | ||
BRCA1 (−0.6) | Regulate cell-cycle progression, DNA damage repair, cell growth and apoptosis | ||
SKI (−0.3) | Regulates cell proliferation | ||
6-0 weeks | TPX2 (0.3) | Involved in cellular proliferation | |
MDM4 (2.0) | Potentially inhibits the G1 phase of the cell cycle | ||
CLU (0.4) | Regulates apoptosis | ||
PROP1 (0.4) | Negatively regulates apoptosis | ||
CCND2 (−0.3) | May play a distinct role in cell cycle progression | ||
SOCS2 (−0.9) | Regulates cell proliferation by terminating the transcription activity | ||
6-3 weeks | SKI (0.3) | Regulates cell proliferation | |
PECR (−0.5) | Regulates apoptosis | ||
BTG3 (−0.9) | Is an anti-proliferative gene | ||
Control Group | |||
3-0 weeks | ESR1 (0.6) | Transcription factor binding | |
BMP2 (−2.8) | Negatively regulates the progression through cell cycle | ||
E2F2 (−0.4) | Helps regulate the expression of a number of genes that are important in cell proliferation | ||
FGF8 (−0.6) | Regulates progression through cell cycle | ||
6-0 weeks | BMPR2 (0.7) | Regulates progression through cell cycle | |
CIB1 (0.5) | Signalling cell death | ||
MPHOSPH9 (0.6) | Regulates progression through cell cycle via M- phase of mitosis | ||
ELMO1 (0.4) | Promotes phagocytosis, cell shape changes and apoptosis | ||
6-3 weeks | DLEC1 (1.0) | Negatively regulates cell proliferation | |
EML4 (−0.3) | Is significantly overexpressed in mitotic cells | ||
PARD6G (−0.4) | Is involved in cell cycle and cell division |