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Table 1 Genes proposed to regulate cell cycle and apoptosis with specific functions according to Ace View[46]

From: The genetic regulation of the terminating phase of liver regeneration

Resection Group

Up-regulated

Down-regulated

Function

3-0 weeks

PRKRA (0.8)

 

Negative regulator of cell proliferation

 

GSK3A (0.3)

 

Negative regulator of cell proliferation

 

IGFBP7 (0.9)

 

Regulation of cell proliferation

  

TIA1 (−1.8)

Inducer of apoptosis

6-0 weeks

ZNF490 (2.0)

 

Negative effect on cell cycle progression and promotes apoptosis

 

CCT7 (0.4)

 

Is implicated in positive control of the G(1)/S phase transition

  

BAG3 (−1.1)

Prevents FAS-mediated apoptosis

  

TP53INP1 (−0.9)

Induces apoptosis

  

TOB (−0.3)

Regulates cell growth

6-3 weeks

ZNF490 (2.4)

 

Negative effect on cell cycle progression and promotes apoptosis

 

CARD11 (0.4)

 

Activates caspases that play a central role in apoptosis

 

PTHLH (0.4)

 

Positive and negative regulator of cell proliferation

  

FAF1 (−1.1)

Increases cell death

Sham Group

   

3-0 weeks

MDM4 (1.9)

 

Potentially inhibits the G1 phase of the cell cycle

 

E2F2 (0.3)

 

Helps regulate the expression of a number of genes that are important in cell proliferation

 

WWOX (0.2)

 

Negatively regulates the progression through the cell cycle

 

UMOD (0.9)

 

Negative regulator of cell proliferation

  

BRCA1 (−0.6)

Regulate cell-cycle progression, DNA damage repair, cell growth and apoptosis

  

SKI (−0.3)

Regulates cell proliferation

6-0 weeks

TPX2 (0.3)

 

Involved in cellular proliferation

 

MDM4 (2.0)

 

Potentially inhibits the G1 phase of the cell cycle

 

CLU (0.4)

 

Regulates apoptosis

 

PROP1 (0.4)

 

Negatively regulates apoptosis

  

CCND2 (−0.3)

May play a distinct role in cell cycle progression

  

SOCS2 (−0.9)

Regulates cell proliferation by terminating the transcription activity

6-3 weeks

SKI (0.3)

 

Regulates cell proliferation

  

PECR (−0.5)

Regulates apoptosis

  

BTG3 (−0.9)

Is an anti-proliferative gene

Control Group

   

3-0 weeks

ESR1 (0.6)

 

Transcription factor binding

  

BMP2 (−2.8)

Negatively regulates the progression through cell cycle

  

E2F2 (−0.4)

Helps regulate the expression of a number of genes that are important in cell proliferation

  

FGF8 (−0.6)

Regulates progression through cell cycle

6-0 weeks

BMPR2 (0.7)

 

Regulates progression through cell cycle

 

CIB1 (0.5)

 

Signalling cell death

 

MPHOSPH9 (0.6)

 

Regulates progression through cell cycle via M- phase of mitosis

 

ELMO1 (0.4)

 

Promotes phagocytosis, cell shape changes and apoptosis

6-3 weeks

DLEC1 (1.0)

 

Negatively regulates cell proliferation

  

EML4 (−0.3)

Is significantly overexpressed in mitotic cells

  

PARD6G (−0.4)

Is involved in cell cycle and cell division