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Table 1 Genes proposed to regulate cell cycle and apoptosis with specific functions according to Ace View[46]

From: The genetic regulation of the terminating phase of liver regeneration

Resection Group Up-regulated Down-regulated Function
3-0 weeks PRKRA (0.8)   Negative regulator of cell proliferation
  GSK3A (0.3)   Negative regulator of cell proliferation
  IGFBP7 (0.9)   Regulation of cell proliferation
   TIA1 (−1.8) Inducer of apoptosis
6-0 weeks ZNF490 (2.0)   Negative effect on cell cycle progression and promotes apoptosis
  CCT7 (0.4)   Is implicated in positive control of the G(1)/S phase transition
   BAG3 (−1.1) Prevents FAS-mediated apoptosis
   TP53INP1 (−0.9) Induces apoptosis
   TOB (−0.3) Regulates cell growth
6-3 weeks ZNF490 (2.4)   Negative effect on cell cycle progression and promotes apoptosis
  CARD11 (0.4)   Activates caspases that play a central role in apoptosis
  PTHLH (0.4)   Positive and negative regulator of cell proliferation
   FAF1 (−1.1) Increases cell death
Sham Group    
3-0 weeks MDM4 (1.9)   Potentially inhibits the G1 phase of the cell cycle
  E2F2 (0.3)   Helps regulate the expression of a number of genes that are important in cell proliferation
  WWOX (0.2)   Negatively regulates the progression through the cell cycle
  UMOD (0.9)   Negative regulator of cell proliferation
   BRCA1 (−0.6) Regulate cell-cycle progression, DNA damage repair, cell growth and apoptosis
   SKI (−0.3) Regulates cell proliferation
6-0 weeks TPX2 (0.3)   Involved in cellular proliferation
  MDM4 (2.0)   Potentially inhibits the G1 phase of the cell cycle
  CLU (0.4)   Regulates apoptosis
  PROP1 (0.4)   Negatively regulates apoptosis
   CCND2 (−0.3) May play a distinct role in cell cycle progression
   SOCS2 (−0.9) Regulates cell proliferation by terminating the transcription activity
6-3 weeks SKI (0.3)   Regulates cell proliferation
   PECR (−0.5) Regulates apoptosis
   BTG3 (−0.9) Is an anti-proliferative gene
Control Group    
3-0 weeks ESR1 (0.6)   Transcription factor binding
   BMP2 (−2.8) Negatively regulates the progression through cell cycle
   E2F2 (−0.4) Helps regulate the expression of a number of genes that are important in cell proliferation
   FGF8 (−0.6) Regulates progression through cell cycle
6-0 weeks BMPR2 (0.7)   Regulates progression through cell cycle
  CIB1 (0.5)   Signalling cell death
  MPHOSPH9 (0.6)   Regulates progression through cell cycle via M- phase of mitosis
  ELMO1 (0.4)   Promotes phagocytosis, cell shape changes and apoptosis
6-3 weeks DLEC1 (1.0)   Negatively regulates cell proliferation
   EML4 (−0.3) Is significantly overexpressed in mitotic cells
   PARD6G (−0.4) Is involved in cell cycle and cell division