Comparative Hepatology

Table 1 Effect of AG28262, a VEGR-2 inhibitor, on serum ALT, ALP and AST enzymatic activity in treated and control rats

From: Evaluation of the effects of a VEGFR-2 inhibitor compound on alanine aminotransferase gene expression and enzymatic activity in the rat liver

Group	Day sampled	ALT (U/L)	ALP (U/L)	AST (U/L)
Control	3	53 ± 2	175 ± 15	99 ± 3
400 mg/kg	3	82 ± 7 *	197 ± 16	111 ± 1
Control	8	55 ± 4	153 ± 12	89 ± 2
400 mg/kg	8	118 ± 19*	209 ± 15*	150 ± 40

Values expressed as mean U/L ± SEM.
*Statistically significant (p ≤ 0.01).

Back to article page