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Table 1 Effect of AG28262, a VEGR-2 inhibitor, on serum ALT, ALP and AST enzymatic activity in treated and control rats

From: Evaluation of the effects of a VEGFR-2 inhibitor compound on alanine aminotransferase gene expression and enzymatic activity in the rat liver

Group Day sampled ALT (U/L) ALP (U/L) AST (U/L)
Control 3 53 ± 2 175 ± 15 99 ± 3
400 mg/kg 3 82 ± 7 * 197 ± 16 111 ± 1
Control 8 55 ± 4 153 ± 12 89 ± 2
400 mg/kg 8 118 ± 19* 209 ± 15* 150 ± 40
  1. Values expressed as mean U/L ± SEM.
  2. *Statistically significant (p ≤ 0.01).