Figure 1

Protection of ILK KO mice against Fas-induced liver injury and apoptosis. A) Kaplan Meier survival curves after a sublethal (0.16 μg/g) (left graph) and a lethal dose (0.40 μg/g) (right graph) of Jo-2. B) Hematoxylin-eosin staining of liver sections at 6 h after a sublethal injection of Jo-2 shows reduced hemorrhage and apoptotic cell bodies in the ILK KO mice. Double arrow = 300 μm. C) Representative Western blots of basal levels of Fas receptor in whole livers and hepatocytes isolated from WT and ILK KO mice.