Hepatic oxidative stress in an animal model of sleep apnoea: effects of different duration of exposure

Comparative Hepatology

Table 1 Enzymes indicating hepatic integrity: AST, ALT and alkaline phosphatase.

Enzymes	SIH	IH-21	IH-35
AST _(U/L)	124.4 ± 6.5	94.36 ± 7.05	145.8 ± 7.2^a
ALT _(U/L)	45.5 ± 4.0	48.50 ± 2.85	55.6 ± 1.3^b
AP _(U/L)	97.7 ± 3.1	84.25 ± 1.98	122.6 ± 2.4^c

Data are presented as mean ± standard error (n = 12 animals/group). ^a IH-35 vs SIH, p = 0,04; ^b IH-35 vs SIH, p = 0,03; ^c IH-35 vs SIH, p < 0,0001. SIH: sham intermittent hypoxia group; IH-21: intermittent hypoxia for 21 days; IH-35: intermittent hypoxia for 35 days; AST: aspartate aminotransferase; ALT: alanine aminotransferase; ALP: alkaline phosphatase.