Figure 7
From: Low affinity glucocorticoid binding site ligands as potential anti-fibrogenics
4A3COOHmethyl administration and liver fibrosis in a rat CCl 4 model of liver fibrosis. Four animals/group (control or 4A3COOHmethyl) or six animals/group (CCl4 or CCl4 + 4A3COOHmethyl) were treated as outlined in the Methods section. Mean and standard deviation serum ALT (a); Mean and standard deviation collagen 1A1 mRNA levels (b); typical views of liver sections stained for sirius red, with a 100 μm scale bar (b); quantitative image analysis for fibrosis – data are the mean and standard deviation percentage sirius red staining from at least 4 separate animals in each treatment with at least 10 randomly selected fields examined for each animal (c).